<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">radiology</journal-id><journal-title-group><journal-title xml:lang="ru">Радиология — практика</journal-title><trans-title-group xml:lang="en"><trans-title>Radiology - Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2713-0118</issn><publisher><publisher-name>Центральный научно-исследовательский институт лучевой диагностики</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52560/2713-0118-2023-5-69-81</article-id><article-id custom-type="elpub" pub-id-type="custom">radiology-484</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ И КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS AND BRIEF REPORTS</subject></subj-group></article-categories><title-group><article-title>Диссеминированный мукормикоз у ребенка с острым лимфобластным лейкозом (клиническое наблюдение)</article-title><trans-title-group xml:lang="en"><trans-title>Disseminated mucormycosis in a child with acute lymphoblastic leukemia (case report)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3582-8783</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щелканова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchelkanova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щелканова Екатерина Сергеевна, врач-ординатор рентгенологического отделения </p><p>117997, Москва, ул. Саморы Машела, д. 1.</p><p>+7 (495) 287-65-70 (доб. 1220)</p></bio><bio xml:lang="en"><p>Shchelkanova Ekaterina S., Resident Doctor of Department Radiation Diagnosis </p><p>1, ul. Samory Mashela, Moscow, 117997</p><p>+7 (495) 287-65-70 (add. 1220)</p></bio><email xlink:type="simple">Dr.Shelkanova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7317-7104</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Терещенко Галина Викторовна, кандидат медицинских наук, старший научный сотрудник отдела лучевой диагностики, заведующая рентгенологическим отделением </p><p>117997, Москва, ул. Саморы Машела, д. 1.</p><p>+7 (495) 287-65-70 (доб. 1220)</p></bio><bio xml:lang="en"><p>Tereshchenko Galina V., Ph.D., Senior Researcher and Head of Radiology department</p><p>1, ul. Samory Mashela, Moscow, 117997</p><p>+7 (495) 287-65-70 (add. 1220)</p></bio><email xlink:type="simple">Galina.Tereshenko@fccho-moscow.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1099-9332</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Краснов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnov</surname><given-names>Alexey S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Краснов Алексей Сергеевич, врач-рентгенолог, научный сотрудник отдела лучевой диагностики</p><p>117997, Москва, ул. Саморы Машела, д. 1.</p><p>+7 (495) 287-65-70 (доб. 1220)</p></bio><bio xml:lang="en"><p>Krasnov Alexey S., Radiologist, Researcher of Department Radiation Diagnosis</p><p>1, ul. Samory Mashela, Moscow, 117997</p><p>+7 (495) 287-65-70 (add. 1220)</p></bio><email xlink:type="simple">Alexey.Krasnov@fccho-moscow.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>09</month><year>2023</year></pub-date><volume>0</volume><issue>5</issue><fpage>69</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Щелканова Е.С., Терещенко Г.В., Краснов А.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Щелканова Е.С., Терещенко Г.В., Краснов А.С.</copyright-holder><copyright-holder xml:lang="en">Shchelkanova E.S., Tereshchenko G.V., Krasnov A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.radp.ru/jour/article/view/484">https://www.radp.ru/jour/article/view/484</self-uri><abstract><p>Мукормикоз является редкой инвазивной грибковой инфекцией, наиболее часто наблюдаемой у пациентов с онкогематологическими заболеваниями при получении химиотерапевтического лечения, особенно в нейтропенической фазе. Ранняя диагностика и вовремя начатое лечение чрезвычайно важны для улучшения прогноза и выживаемости пациента.</p><p>В данной статье мы представляем клинический случай с очень редким вариантом диссеминированного мукормикоза с вовлечением селезенки и средостения у ребенка 21 месяца, обусловленного Lichtheimia spp. </p></abstract><trans-abstract xml:lang="en"><p>Mucormycosis is a rare invasive fungal infection most commonly seen in patients with oncological and hematological diseases, when receiving chemotherapy treatment especially in the neutropenic phase. Early diagnosis and timely initiation of treatment are extremely important to improve the prognosis and survival of the patient.</p><p>In this article, we present a clinical case of a very rare variant of disseminated mucormycosis with involvement of the spleen and mediastinum in a 21-month-old child due to Lichtheimia spp.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мукормикоз</kwd><kwd>лейкоз</kwd><kwd>множественные абсцессы</kwd><kwd>лучевая диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Mucormycosis</kwd><kwd>Leukemia</kwd><kwd>Multiple Abscesses</kwd><kwd>Radiology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Климко Н. Н., Хостелиди С. Н., Шадривова О. В и др. Инвазивный мукормикоз у онкогематологических больных (результаты проспективного исследования) // Онкогематология. 2017;12(2):1422. DOI: 10.17650/1818834620171221422</mixed-citation><mixed-citation xml:lang="en">Klimko N. N., Khostelidi S. N., Shadr ivova O. V et al. Mucormycosis in onc ohematology patiens (results of the prospective study). Oncohematology. 2017; 12(2):14-22. (In Russ.). https://doi.org/10.17650/1818-8346-2017-12-2-14-22</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Хостелиди С. Н., Шадривова О. В., Борзова Ю В. и др. Клинико-лабораторные особенности мукормикроза у взрослых // Проблемы медицинской микологии. 2020. T. 22(2). C. 22–28. DOI: 10.24412/1999-6780-2020-2-22-28</mixed-citation><mixed-citation xml:lang="en">Hostelidi S. N., Shadrivova O. V., Borzo va Ju. V. et al. Clinical and laboratory features of mucormicosis in adults. Problems in medi cal mycology. 2020. Vol. 22 (2). P. 22–28. (In Russ.). DOI: 10.24412/1999-6780-2020-2-22-28</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Agrawal R., Yeldandi A., Savas H. et al. Pulmonary Mucormycosis: Risk Factors, Radiologic Findings, and Pathologic Correlation. Radiographics. 2020 MayJun;40(3):656-666. DOI: 10.1148/rg.2020190156. Epub 2020 Mar 20. PMID: 32196429.</mixed-citation><mixed-citation xml:lang="en">Agrawal R., Yeldandi A., Savas H. et al. Pulmonary Mucormycosis: Risk Factors, Radiologic Findings, and Pathologic Corr elation. Radiographics. 2020 May-Jun;40(3): 656-666. DOI: 10.1148/rg.2020190156. Epub 2020 Mar 20. PMID: 32196429.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Batool S. M., Mubarak F., Enam S. A. Diffusion-weighted magnetic resonance imaging may be useful in differentiating fungal abscess from malignant intracranial lesion: Case report. Surg. Neurol. Int. 2019 Jan 25;10:13. DOI: 10.4103/sni.sni_300_18. PMID: 30788184; PMCID: PMC6367948.</mixed-citation><mixed-citation xml:lang="en">Batool S. M., Mubarak F., Enam S. A. Diffusion-weighted magnetic resonance imaging may be useful in differentiating fungal abscess from malignant intracranial lesion: Case report. Surg. Neurol. Int. 2019 Jan 25;10:13. DOI: 10.4103/sni.sni_300_18. PMID: 30788184; PMCID: PMC6367948.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chamilos G., Lewis R. E., Kontoyiannis D. P. Delaying Amphotericin B-Based Frontline Therapy Significantly Increases Mortality among Patients with Hematologic Malignancy Who Have Zygomycosis. Clinical Infectious Diseases. Vol. 47. Issue 4. 15 August 2008. P. 503–509, https://doi.org/10.1086/590004</mixed-citation><mixed-citation xml:lang="en">Chamilos G., Lewis R. E., Kontoyiannis D. P. Delaying Amphotericin B–Bas ed Frontline Therapy Significantly Increases Mortality among Patients with Hema tologic Malignancy Who Have Zygo mycosis. Clinical Infectious Diseases. V. 47. Issue 4. 15 August 2008. Pages 503–509. https://doi.org/10.1086/590004</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chen L., Peng W., Lan G. et al. The application of metagenomic nextgeneration sequencing in patients with infection or colonization caused by Lichtheimia species. Front. Cell. Infect. Microbiol. 2023 Mar 28;13:1103626. DOI: 10.3389/fcimb.2023.1103626. PMID: 37056706; PMCID: PMC10087083.</mixed-citation><mixed-citation xml:lang="en">Chen L., Peng W., Lan G. et al. The application of metagenomic nextgeneration sequencing in patients with infection or colonization caused by Lichtheimia species. Front Cell Infect Microbiol. 2023 Mar 28;13:1103626. DOI: 10.3389/fcimb.2023.1103626. PMID: 37056706; PMCID: PMC10087083.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cooper J. D., Gotoff R. A., Foltzer M. A., Carter R. A., Walsh T. J. Mediastinal mucormycosis: case report, review of literature and treatment with continuous liposomal amphotericin B irrigation. Mycoses. 2019;62(9):739–745. DOI: 10.1111/myc.12922</mixed-citation><mixed-citation xml:lang="en">Cooper J. D., Gotoff R. A., Foltzer M. A., Carter R. A., Walsh T. J. Mediastinal mucormycosis: case report, review of literature and treatment with continuous liposomal amphotericin B irrigation. Myco ses. 2019;62(9):739-745. DOI: 10.11 11/myc.12922</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Coste A., Conrad A., Porcher R., Poiree S. et al. French Mycosis Study Group. Improving diagnosis of pulmonary mucormycosis: leads from a contemporary national study of 114 cases. Chest. 2023 Jul 5: S0012-3692(23)00946-7. DOI: 10.1016/j.chest.2023.06.039</mixed-citation><mixed-citation xml:lang="en">Coste A., Conrad A., Porcher R., Poiree S. et al. French Mycosis Study Group. Improving diagnosis of pulmonary mucormycosis: leads from a contemporary national study of 114 cases. Chest. 2023 Jul 5:S0012-3692(23)00946-7. DOI: 10.1016/j.chest.2023.06.039</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hernandez J. L., Buckley C. J. Mucormycosis. 2023 Jun 12. In: StatPearls [Inter net]. Treasure Island (FL): StatPearls Pub lishing; 2023 Jan. PMID: 313 35084.</mixed-citation><mixed-citation xml:lang="en">Hernandez J. L., Buckley C. J. Mucormycosis. 2023 Jun 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. PMID: 31335084.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Jeong W., Keighley C., Wolfe R. et al. The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports. Clin. Microbiol. Infect. 2019;25(1):26-34.</mixed-citation><mixed-citation xml:lang="en">Jeong W., Keighley C., Wolfe R. et al. The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports. Clin. Microbiol. Infect. 2019;25(1):26-34.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kalogerakos P. D., Kiparakis M., Pavlaki K., Pontikoglou C., Lazopoulos G., Chalkiadakis G. Thoracoabdominal Resection of Mucormycosis Lesions in a Leukemic Patient. Ann. Thorac. Surg. 2018 Nov;106(5):e239-e241. DOI: 10.1016/j.athoracsur.2018.04.066</mixed-citation><mixed-citation xml:lang="en">Kalogerakos P. D., Kiparakis M., Pavlaki K., Pontikoglou C., Lazopoulos G., Chalkiadakis G. Thoracoabdominal Resection of Mucormycosis Lesions in a Leukemic Patient. Ann. Thorac. Surg. 2018 Nov; 106(5):e239-e241. DOI: 10.1016/j.athoracsur.2018.04.066</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Khan A. A., Kumaran V., Jain D., Siraj F., Aggarwal S. Hepatic mucormycosis in a patient of acute lymphoblastic leukemia: a case report with literature review. Indian J. Hematol. Blood Transfus. 2013 Jun; 29(2):96-8. DOI: 10.1007/s12288012-0148-9. PMID: 24426347; PMCID: PMC3636350.</mixed-citation><mixed-citation xml:lang="en">Khan A. A., Kumaran V., Jain D., Siraj F., Aggarwal S. Hepatic mucormycosis in a patient of acute lymphoblastic leukemia: a case report with literature review. Indian J. Hematol. Blood Transfus. 2013 Jun; 29(2):96-8. DOI: 10.1007/s12288012-0148-9. PMID: 24426347; PMCID: PMC3636350.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Luo S., Huang X., Li Y., Wang J. Isolated splenic mucormycosis secondary to diabetic ketoacidosis: a case report. BMC Infect. Dis. 2022 Jul 7;22(1):596. DOI: 10.1186/s12879-022-07564-3. PMID: 357 99111; PMCID: PMC9264645.</mixed-citation><mixed-citation xml:lang="en">Luo S., Huang X., Li Y., Wang J. Isolated splenic mucormycosis secondary to diabetic ketoacidosis: a case report. BMC Infect. Dis. 2022 Jul 7;22(1):596. DOI: 10.1186/s12879-022-07564-3. PMID: 35799111; PMCID: PMC9264645.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mekki S. O., Hassan A. A., Falemban A. et al. Pulmonary Mucormycosis: A Case Report of a Rare Infection with Po ten tial Diagnostic Problems. Case Rep. Pathol. 2020 Jan 6;2020:5845394. DOI: 10.1155/2020/5845394. PMID: 31970007; PMCID: PMC6973180.</mixed-citation><mixed-citation xml:lang="en">Mekki S. O., Hassan A. A., Falemban A. et al. Pulmonary Mucormycosis: A Case Report of a Rare Infection with Potential Diagnostic Problems. Case Rep. Pathol. 2020 Jan 6;2020:5845394. DOI: 10.1155/2020/5845394. PMID: 31970007; PMCID: PMC6973180.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nadeem A. M., Wahla A. S., Al-Tarifi A. Invasive Mediastinal Mucormycosis with Pulmonary and Cardiac Involvement in an Adult with Chronic Granulomatous Disease: Case Report and Review of the Literature. Eur. J. Case Rep. Intern. Med. 2021 May 5;8(5):002435. DOI: 10.12890/2021_002435. PMID: 34123938; PMCID: PMC8191362.</mixed-citation><mixed-citation xml:lang="en">Nadeem A. M., Wahla A. S., Al-Tarifi A. Invasive Mediastinal Mucormycosis with Pulmonary and Cardiac Involvement in an Adult with Chronic Granulomatous Disease: Case Report and Review of the Literature. Eur. J. Case Rep. Intern. Med. 2021 May 5;8(5):002435. DOI: 10.12890/2021_002435. PMID: 34123938; PMCID: PMC8191362.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Nevitt P., Das Narla L., Hingsberge E. Mucormycosis resulting in a pseudoaneurysm in the spleen. Pediatric Radiology. 2001;31:115-116. https://doi.org/10.1007/s002470000383</mixed-citation><mixed-citation xml:lang="en">Nevitt P., Das Narla L., Hingsberge E. Mucormycosis resulting in a pseudoaneurysm in the spleen. Pediatric Radiology. 2001;31:115-116. https://doi.org/10.1007/s002470000383</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Roden M. M., Zaoutis T. E., Buchanan W. L. et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin. Infect. Dis. 2005 Sep 1;41(5):634-53. DOI: 10.1086/432579. PMID: 16080086.</mixed-citation><mixed-citation xml:lang="en">Roden M. M., Zaoutis T. E., Buchanan W. L. et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005 Sep 1;41(5):634-53. DOI: 10.1086/432579. PMID: 16080086.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Skiada A., Lass-Floerl C., Klimko N, Ibrahim A., Roilides E., Petrikkos G. Challenges in the diagnosis and treatment of mucormycosis. Med Mycol. 2018 Apr 1;56(suppl_1):93-101. DOI: 10.1093/mmy/myx101. PMID: 29538730; PMCID: PMC6251532.</mixed-citation><mixed-citation xml:lang="en">Skiada A., Lass-Floerl C., Klimko N, Ibrahim A., Roilides E., Petrikkos G. Challenges in the diagnosis and treatment of mucormycosis. Med. Mycol. 2018 Apr 1;56(suppl_1):93-101. DOI: 10.1093/mmy/myx101. PMID: 29538730; PMCID: PMC6251532.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Yang N., Zhang L., Feng S. Clinical Features and Treatment Progress of Invasive Mucormycosis in Patients with Hematological Malignancies. J. Fungi (Basel). 2023 May 19;9(5):592. DOI: 10.3390/jof9050592. PMID: 37233303; PMCID: PMC10219352.</mixed-citation><mixed-citation xml:lang="en">Yang N., Zhang L., Feng S. Clinical Features and Treatment Progress of Invas ive Mucormycosis in Patients with Hematological Malignancies. J. Fungi (Basel). 2023 May 19;9(5):592. DOI: 10.3390/jof9050592. PMID: 37233303; PMCID: PMC10219352.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
