radiologyРадиология — практикаRadiology - Practice2713-0118Центральный научно-исследовательский институт лучевой диагностики10.52560/2713-0118-2024-1-85-103radiology-525Research ArticleМЕДИЦИНСКИЕ ТЕХНОЛОГИИMEDICAL TECHNOLOGIESМагнитно-резонансная релаксометрия в оценке морфологических характеристик глиом головного мозга: современное состояние вопросаMagnetic resonance relaxometry in assessment of morphological properties of brain gliomas: state of the arthttps://orcid.org/0000-0002-6652-2472ЧехонинИ. В.ChekhoninI. V.

Чехонин Иван Владимирович, кандидат медицинских наук, врач-рентгенолог, младший научный сотрудник отделения рентгеновских и радиоизотопных методов диагностики

125047, г. Москва, 4-я Тверская-Ямская ул, д. 16

+7 (903) 292-11-53

Chekhonin Ivan Vladimirovich, M. D., Ph. D. Med., radiologist, junior research associate, Department of X-ray and Radioisotope Diagnostic Methods

16, 4th Tverskaya-Yamskaya ul., Moscow, 125047

+7 (903) 292-11-53

ivan.chekhonin@gmail.comhttps://orcid.org/0000-0002-8924-7346БаталовА. И.BatalovA. I.

Баталов Артем Игоревич, кандидат медицинских наук, врач-рентгенолог, старший научный сотрудник отделения рентгеновских и радиоизотопных методов диагностики

125047, г. Москва, 4-я Тверская-Ямская улица, д. 16

+7 (916) 066-20-50

Batalov Artem Igorevich, M. D., Ph. D. Med., radiologist, senior research associate, Department of X-ray and Radioisotope Diagnostic Methods

16, 4th Tverskaya-Yamskaya ul., Moscow, 125047

+7 (916) 066-20-50

abatalov@nsi.ruhttps://orcid.org/0000-0002-0516-3613ЗахароваН. Е.ZakharovaN. E.

Захарова Наталья Евгеньевна, доктор медицинских наук, профессор РАН, ведущий научный сотрудник отделения рентгеновских и радиоизотопных методов диагностики ФГАУ «НМИЦ нейрохирургии им. ак. Н. Н. Бурденко» Минздрава России

125047, г. Москва, 4-я Тверская-Ямская улица, д. 16

+7 (499) 972-85-55

Zakharova Natal’ya Evgen’evna, M. D., D. Sci. Med., Professor of the Russian Academy of Sciences, Leading Researcher, Department of X-ray and Radioisotope Diagnostic Methods, Federal State Autonomous Institution N. N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

16, 4th Tverskaya-Yamskaya ul., Moscow, 125047

+7 (499) 972-85-55

nzakharova@nsi.ruhttps://orcid.org/0000-0002-0487-1183КорниенкоВ. Н.KornienkoV. N.

Корниенко Валерий Николаевич, доктор медицинских наук, профессор, академик РАН, научный консультант отделения рентгеновских и радиоизотопных методов диагностики ФГАУ «НМИЦ нейрохирургии им. ак. Н. Н. Бурденко» Минздрава России

125047, г. Москва, 4-я Тверская-Ямская улица, д. 16

+7 (499) 972-85-55

Kornienko Valeriy Nikolaevich, M. D., D. Sci. Med., Academician of the Russian Academy of Sciences, Scientific Consultant, Department of X-ray and Radioisotope Diagnostic Methods, Federal State Autonomous Institution N. N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

16, 4th Tverskaya-Yamskaya ul., Moscow, 125047

+7 (499) 972-85-55

kornienko@nsi.ruhttps://orcid.org/0000-0002-4480-0275ПронинИ. Н.ProninI. N.

Пронин Игорь Николаевич, доктор медицинских наук, профессор, академик РАН, заведующий отделением рентгеновских и радиоизотопных методов диагностики ФГАУ «НМИЦ нейрохирургии им. ак. Н. Н. Бурденко» Минздрава России

125047, г. Москва, 4-я Тверская-Ямская улица, д. 16

+7 (499) 972-85-55

Pronin Igor’ Nikolaevich, M. D., D. Sci. Med., Academician of the Russian Academy of Sciences, Head of Department of X-ray and Radioisotope Diagnostic Methods, Federal State Autonomous Institution N. N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

16, 4th Tverskaya-Yamskaya ul., Moscow, 125047

+7 (499) 972-85-55

pronin@nsi.ruФГАУ «НМИЦ нейрохирургии им. ак. Н. Н. Бурденко» Минздрава РоссииРоссияFederal State Autonomous Institution «N. N. Burdenko National Medical Research Center of Neurosurgery» of the Ministry of Health of the Russian FederationRussian Federation2024120120240185103Copyright © Чехонин И.В., Баталов А.И., Захарова Н.Е., Корниенко В.Н., Пронин И.Н., 20242024Чехонин И.В., Баталов А.И., Захарова Н.Е., Корниенко В.Н., Пронин И.Н.Chekhonin I.V., Batalov A.I., Zakharova N.E., Kornienko V.N., Pronin I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.radp.ru/jour/article/view/525

Магнитно-резонансная (МР) релаксометрия — методика измерения тканевых релаксационных показателей — является способом количественной визуализации физической основы структурных МР-изображений. Настоящий обзор посвящен перспективным направлениям изучения и применения МР-релаксометрии в диагностике глиом головного мозга на предоперационном и предтерапевтическом этапе. Наряду с анализом работ ведущих мировых коллективов приводятся результаты собственных исследований. Накопленная информация свидетельствует о появлении возможностей дифференцирования глиом различных степеней злокачественности, несмотря на определенное сходство их релаксометрических характеристик, а также о потенциале метода в дифференциальной диагностике глиом и опухолей иного генеза. Ряд результатов может свидетельствовать о наличии изменений МР-сигнала, связанных с инфильтративным ростом глиом. Отдельно рассмотрены работы, направленные на поиск наиболее агрессивных и злокачественных участков в ткани глиом, что может быть крайне полезным при планировании биопсии или удаления опухоли. Не меньшую значимость имеют возможности МР-релаксометрии в контексте радиогеномики, в первую очередь в оценке IDH-статуса глиом.

Magnetic resonance (MR) relaxometry, or measurement of tissue magnetic relaxation properties, is a technology intended to quantitatively depict the physical basis of structural MR imaging. This review is devoted to perspective directions of studies and application of MR relaxometry in brain glioma preoperative and pretherapeutic diagnosis. The current data advocate for emerging capabilities of relaxometry in glioma grading (despite possible overlap between different grades) and differentiating between gliomas and tumors of other origin. Some studies showed features of relaxometric values within the perifocal infiltrative edema zone possibly related to glioma infiltrative growth. We separately reviewed the works aimed at searching for the most aggressive and malignant foci in glioma tissue and extremely useful for tumor biopsy or removal. No less important are capabilities of relaxometry in radiogenomics, first of all, in IDH status prediction. The relaxometric method possesses perspective in multiparametric brain glioma diagnostics.

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The authors declare that there are no conflicts of interest present.