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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">radiology</journal-id><journal-title-group><journal-title xml:lang="ru">Радиология — практика</journal-title><trans-title-group xml:lang="en"><trans-title>Radiology - Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2713-0118</issn><publisher><publisher-name>Центральный научно-исследовательский институт лучевой диагностики</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52560/2713-0118-2025-1-27-41</article-id><article-id custom-type="elpub" pub-id-type="custom">radiology-674</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Изучение параметров диффузионно-тензорной МРТ плечевых сплетений и их взаимосвязи с биометрическими и демографическими показателями в норме</article-title><trans-title-group xml:lang="en"><trans-title>The Study of the Parameters of Diffusion Tensor MRI of Brachial Plexuses and Parameters Correlations with Demographic and Anthropometric Data</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2285-2725</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синькова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sin’kova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Синькова Виктория Викторовна, врач-рентгенолог, аспирант отдела лучевой диагностики</p><p>Москва</p><p>Вклад автора: нейровизуализационное обследование испытуемых, обзор публикаций по теме статьи, разметка обработанных данных для получения количественных параметров, статистический анализ данных, написание статьи, подготовка иллюстраций</p></bio><bio xml:lang="en"><p>Sin’kova Viktoriya Viktorovna, Рostgraduate, Radiologist of the Department of Neuroradiology</p><p>Moscow</p><p>Author’s contribution: MRI examination, review of publications on the topic of the article, ROI placement and data collection, statistical analysis, writing the article, illustrations preparing</p></bio><email xlink:type="simple">000564321@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9093-344X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозова Софья Николаевна, врач-рентгенолог, кандидат медицинских наук, научный сотрудник отделения лучевой диагностики </p><p>Москва</p><p>Вклад автора: нейровизуализационное обследование испытуемых, обзор публикаций по теме статьи</p></bio><bio xml:lang="en"><p>Morozova Sofya Nikolaevna, Cand. Sci. (Med.), researcher, Neuroradiology department</p><p>Moscow</p><p>Author’s contribution: MRI examination, review of publications on the topic of the article</p></bio><email xlink:type="simple">morozova@neurology.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7924-3405</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришина</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishina</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гришина Дарья Александровна, кандидат медицинских наук, руководитель Центра заболеваний периферической нервной системы Института клинической и профилактической неврологии</p><p>Москва</p><p>Вклад автора: обзор публикаций по теме статьи, научная консультация, контроль отсутствия поражения плечевых сплетений у здоровых добровольцев</p></bio><bio xml:lang="en"><p>Grishina Daria Aleksandrovna, Cand. Sci. (Med.), Head, Center for Peripheral Nervous System Diseases, Institute of Clinical and Preventive Neurology</p><p>Moscow</p><p>Author’s contribution: review of publications on the topic of the article, confirmation of absence of brachial plexus damage in volunteers, scientific consultation, text editing</p></bio><email xlink:type="simple">dgrishina82@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9538-9690</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тумилович</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tumilovich</surname><given-names>T. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тумилович Таисия Александровна, врач-невролог Центра заболеваний периферической нервной системы Института клинической и профилактической неврологии </p><p>Москва</p><p>Вклад автора: подбор испытуемых для включения в исследование</p></bio><bio xml:lang="en"><p>Tumilovich Taisiya Aleksandrovna, Neurologist, Center for Peripheral Nervous System Diseases, Institute of Clinical and Preventive Neurology</p><p>Moscow</p><p>Author’s contribution: healthy controls recruitment</p></bio><email xlink:type="simple">md.tumilovich@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3956-6362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Супонева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Suponeva</surname><given-names>N. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Супонева Наталья Александровна, доктор медицинских наук, член-корреспондент РАН, профессор, директор Института нейрореабилитации и восстановительной медицины</p><p>Москва</p><p>Вклад автора: научная консультация, концептуализация исследования, написание статьи</p></bio><bio xml:lang="en"><p>Suponeva Natalia Aleksandrovna, D. Sci. (Med.), Corresponding Member of RAS, Director, Institute of Neurorehabilitation and Rehabilitation Medicine</p><p>Moscow</p><p>Author’s contribution: scientific consultation, review conceptualization, text editing</p></bio><email xlink:type="simple">nasu2709@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Научный центр&#13;
неврологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center of Neurology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>27</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Синькова В.В., Морозова С.Н., Гришина Д.А., Тумилович Т.А., Супонева Н.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Синькова В.В., Морозова С.Н., Гришина Д.А., Тумилович Т.А., Супонева Н.А.</copyright-holder><copyright-holder xml:lang="en">Sin’kova V.V., Morozova S.N., Grishina D.A., Tumilovich T.А., Suponeva N.А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.radp.ru/jour/article/view/674">https://www.radp.ru/jour/article/view/674</self-uri><abstract><p>Знания числовых значений параметров диффузионно-тензорной магнитно-резонансной томографии (ДТ-МРТ) в норме, а также их взаимосвязь с демографическими, биометрическими показателями и основными параметрами стандартной МРТ важны для диагностики патологических изменений плечевых сплетений, особенно в случае неспецифичных или неоднозначных изменений по данным стандартной МРТ.</p><sec><title>Цель исследования</title><p>Цель исследования. Оценка возможности применения ДТ-МРТ для исследования плечевых сплетений, формирование алгоритма обработки данных и оценка распределения значений параметров в норме, а также исследование наличия их взаимосвязи с социально-демографическими и антропометрическими показателями.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование были включены 50 здоровых добровольцев без признаков поражения периферической нервной системы (НС). Параметры ДТ-МРТ регистрировались на расстоянии 1–2 см от спинального ганглия с обеих сторон с помощью рабочей станции Siemens с ручным выставлением зоны интереса. Регистрировались такие параметры, как фракционная анизотропия, средняя диффузионная способность, аксиальный и радиальный коэффициенты диффузии. Кроме того, измерялся коэффициент интенсивности в той же точке при помощи стандартной трехмерной последовательности с подавлением сигнала от жировой ткани STIR.</p></sec><sec><title>Результаты</title><p>Результаты. Были получены средние значения для каждого оцениваемого параметра. Статистически значимым оказалось различие фракционной анизотропии (ФА) между сторонами: справа существенно выше, чем слева. Также при корреляционном анализе отмечалась обратная взаимосвязь аксиальной диффузии (АД) с возрастом испытуемых с обеих сторон. А при разделении испытуемых по полу у мужчин были выявлены достоверно закономерно большие диаметр нерва, диаметр подключичной артерии, рост и вес.</p></sec><sec><title>Заключение</title><p>Заключение. Наличие значимой отрицательной связи между АД с обеих сторон и возрастом может свидетельствовать о постепенном истончении нервного волокна с возрастом, различие измеряемых показателей у испытуемых разного пола и их зависимость от биометрических показателей закономерны, и это следует учитывать при интерпретации исследований у пациентов с различными патологическими состояниями, а существенное отличие ФА по сторонам не позволяет интерпретировать полученные данные по типу смешанной модели и требует рассмотрения числовых параметров для каждой из сторон отдельно.</p></sec></abstract><trans-abstract xml:lang="en"><p>It is crucial to know the numerical values of diffusion tensor magnetic resonance imaging (DTMRI) parameters in healthy subjects, as well as their correlation with demographic, biometric data and the key parameters of standard MRI, for the purpose of diagnosing pathological changes in brachial plexuses, especially when dealing with non-specific or unclear alterations according to standard magnetic resonance imaging finding.</p><sec><title>Aim</title><p>Aim. Assessing the potential of using diffusion tensor magnetic resonance imaging (DTMRI) to study brachial plexuses, developing an algorithm for data processing and evaluating the distribution of parameter values in normal conditions, as well as exploring whether they correlate with socio-demographic and anthropometric indicators.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. The study included 50 healthy volunteers without signs of damage to the peripheral nervous system. The diffusion tensor MRI parameters were recorded at a distance of 1–2 cm from the spinal ganglion on both sides using the Siemens workstation with manual setting of the area of interest. Parameters such as fractional anisotropy, mean diffusivity, axial and radial diffusion coefficients were recorded. In addition, the intensity coefficient was measured at the same point using a standard three-dimensional sequence STIR images.</p></sec><sec><title>Results</title><p>Results. The average values for each assessed parameter were obtained. A statistically significant difference in FA was found between the sides, with the right side being significantly higher than the left. Additionally, a negative correlation was observed between AD and the age of the subjects on both sides. When the subjects were categorized by gender, men exhibited significantly larger nerve diameter, subclavian artery diameter, height, and weight.</p></sec><sec><title>Conclusion</title><p>Conclusion. The presence of a significant negative correlation between AD on both sides and age may indicate a gradual thinning of nerve fibers as one ages. The differences in measured parameters among subjects of different genders and their dependence on biometric indicators are consistent and should be taken into account when interpreting studies in patients with various pathological conditions. Furthermore, the substantial difference in the functional asymmetry between sides prevents the interpretation of the obtained data using a mixed model and necessitates the examination of numerical parameters for each side separately.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>магнитно-резонансная томография</kwd><kwd>диффузионно-тензорная МРТ</kwd><kwd>плечевые сплетения</kwd><kwd>количественные методики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Magnetic Resonance Imaging</kwd><kwd>Diffusion Tensor MRI</kwd><kwd>Brachial Plexus</kwd><kwd>Quantitative Methods</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не финансировалось какими-либо источниками.</funding-statement><funding-statement xml:lang="en">The study was not funded by any sources.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Варакин Ю. Я., Горностаева Г. В., Манвелов Л. С., Константинов В.В., Суслина З. A. Клинико-эпидемиологическое исследование патологии нервной системы по данным скрининга открытой популяции // Анналы клинической и экспериментальной неврологии. 2012. Т. 6, № 1. С. 6–13.</mixed-citation><mixed-citation xml:lang="en">Varakin Yu. Ya., Gornostaeva G. V., Manvelov L. S., Konstantinov V. V., Suslina Z. A. Clinical and epidemiological study of the nervous system diseases according to screening of the open population. Annals of Clinical and Experimental Neurology. 2012;6(1):6-13. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Морозова С. Н., Синькова В. В., Гришина Д. А., Тумилович Т. А., Чечеткин А. О., Кротенкова М. В., Супонева Н. А. Основы стандартной визуализации периферической нервной системы: МР-нейрография // Digital Diagnostics. 2023. Т. 4, № 3. C. 356–368. https://doi.org/10.17816/DD430292</mixed-citation><mixed-citation xml:lang="en">Morozova S. N., Sin’kova V. V., Grishina D. A., Tumilovich T. A., Chechetkin A. O., Krotenkova M. V., Suponeva N. A. Conventional magnetic resonance imaging of peripheral nerves: MR-neurography. Digital Diagnostics. 2023;4(3):356-368. (In Russ.). https://doi.org/10.17816/DD430292</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Синькова В. В., Морозова С. Н., Гришина Д. А., Тумилович Т. А., Кротенкова М. В., Супонева Н. А. Роль коэффициента интенсивности МР-сигнала в дифференциальной диагностике мультифокальной моторной нейропатии и синдрома Льюиса — Самнера // Анналы клинической и экспериментальной неврологии. 2025 (принята в печать, № 3).</mixed-citation><mixed-citation xml:lang="en">Sin’kova V. V., Morozova S. N., Grishina D. A., Tumilovich T. A., Krotenkova M. V., Suponeva N. A. The Role of Quantitative Approach in Evaluating Standard MRI of Brachial Plexus in the Diagnosis of Multifocal Motor Neuropathy and LewisSumner Syndrome. Annals of Clinical and Experimental Neurology. 2025;3. (accepted for publication) (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Aoki S., Masutani Y., Abe O. Magnetic resonance diffusion tractography in the brain — its application and limitation. Brain Nerve. 2007;59(5):467-76. Japanese. PMID: 17533972.</mixed-citation><mixed-citation xml:lang="en">Aoki S., Masutani Y., Abe O. Magnetic resonance diffusion tractography in the brain — its application and limitation. Brain Nerve. 2007;59(5):467-76. Japanese. PMID: 17533972.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chhabra A., Thakkar R. S., Andreisek G., Chalian M., Belzberg A. J., Blakeley J., Hoke A., Thawait G. K., Eng J., Carrino J. A. Anatomic MR Imaging and Functional Diffusion Tensor Imaging of Peripheral Nerve Tumors and Tumorlike Conditions. Am. J. Neuroradiol. 2013;34:802-807. PMID: 23124644</mixed-citation><mixed-citation xml:lang="en">Chhabra A., Thakkar R. S., Andreisek G., Chalian M., Belzberg A. J., Blakeley J., Hoke A., Thawait G. K., Eng J., Carrino J. A. Anatomic MR Imaging and Functional Dif¬fusion Tensor Imaging of Peripheral Nerve Tumors and Tumorlike Conditions. Am. J. Neuroradiol. 2013;34: 802-807. PMID: 23124644.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gooch C. L., Weimer L. H. The electrodiagnosis of neuropathy: basic principles and common pitfalls. Neurol. Clin. 2007;25:1-28. https://doi.org/10.1016/j.ncl.2007.01.011</mixed-citation><mixed-citation xml:lang="en">Gooch C. L., Weimer L. H. The electrodiagnosis of neuropathy: basic principles and common pitfalls. Neurol. Clin. 2007; 25:1-28. https://doi.org/10.1016/j.ncl.2007.01.011</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hammi C., Yeung B. Neuropathy. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2023. Free Books &amp; Documents. PMID: 31194377.</mixed-citation><mixed-citation xml:lang="en">Hammi C., Yeung B. Neuropathy. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2023. Free Books &amp; Documents. PMID: 31194377.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Haun D. W., Cho J. C. S. S., Kettner N. W. Normative cross-sectional area of the C5- C8 nerve roots using ultrasonography. Ultrasound Med. Biol. 2010;36:1422-30. https://doi.org/10.1016/j.ultrasmedbio.2010.05.012</mixed-citation><mixed-citation xml:lang="en">Haun D. W., Cho J. C. S. S., Kettner N. W. Normative cross-sectional area of the C5- C8 nerve roots using ultrasonography. Ultrasound Med. Biol. 2010;36:1422-30. https://doi.org/10.1016/j.ultrasmedbio.2010.05.012</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Jellison B. J., Field A. S., Medow J., Lazar M., Salamat M. S., Alexander A. L. Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am. J. Neuroradiol. 2004;25(3):356-69. PMID: 15037456; PMCID: PMC8158568.</mixed-citation><mixed-citation xml:lang="en">Jellison B. J., Field A. S., Medow J., Lazar M., Salamat M. S., Alexander A. L. Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am. J. Neuroradiol. 2004;25(3):356-69. PMID: 15037456; PMCID: PMC8158568.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies / Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society — first revision. Journal of the Peripheral Nervous System. 2010;15(4):295-301. https://doi.org/10.1111/j.1529-8027.2010.00290.x</mixed-citation><mixed-citation xml:lang="en">Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies / Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society — first revision. Journal of the Peripheral Nervous System. 2010;15(4):295-301. https://doi.org/10.1111/j.1529-8027.2010.00290.x</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kwee R. M., Chhabra A., Wang K. C., Marker D. R., Carrino J. A. Accuracy of MRI in Diagnosing Peripheral Nerve Disease: A Systematic Review of the Literature. Am. J. Roentgenol. 2014;203: 1303-1309. https://doi.org/10.2214/AJR.13.12403</mixed-citation><mixed-citation xml:lang="en">Kwee R. M., Chhabra A., Wang K. C., Marker D. R., Carrino J. A. Accuracy of MRI in Diagnosing Peripheral Nerve Disease: A Systematic Review of the Literature. Am. J. Roentgenol. 2014;203: 1303-1309. https://doi.org/10.2214/AJR.13.12403</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Le Bihan D., Breton E., Lallemand D., Grenier P., Cabanis E., Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986;161:401-407. https://doi.org/10.1148/radiology.161.2.3763909</mixed-citation><mixed-citation xml:lang="en">Le Bihan D., Breton E., Lallemand D., Grenier P., Cabanis E., Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986;161:401-407. https://doi.org/10.1148/radiology.161.2.3763909</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lehmann H. C., Zhang J., Mori S., Sheikh K. A. Diffusion tensor imaging to assess axonal regeneration in peripheral nerves. Exp. Neurol. Elsevier Inc. 2010;223:238- 244. https://doi.org/10.1016/j.expneurol.2009.10.012</mixed-citation><mixed-citation xml:lang="en">Lehmann H. C., Zhang J., Mori S., Sheikh K. A. Diffusion tensor imaging to assess axonal regeneration in peripheral nerves. Exp. Neurol. Elsevier Inc. 2010;223:238- 244. https://doi.org/10.1016/j.expneurol.2009.10.012</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lozeron P., Lacour M-C., Vandendries C., Théaudin M., Cauquil C., Denier C. Lacroix C., Adams D. Contribution of plexus MRI in the diagnosis of atypical chronic inflammatory demyelinating polyneuropathies. J. Neurol. Sci. 2016;360:170-5. https://doi.org/10.1016/j.jns.2015.11.048</mixed-citation><mixed-citation xml:lang="en">Lozeron P., Lacour M-C., Vandendries C., Théaudin M., Cauquil C., Denier C. Lacroix C., Adams D. Contribution of plexus MRI in the diagnosis of atypical chronic inflammatory demyelinating polyneuropathies. J. Neurol. Sci. 2016;360:170-5. https://doi.org/10.1016/j.jns.2015.11.048</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mathys C., Aissa J., Zu Hörste G. M., Reichelt D. C., Antoch G., Turowski B., Hartung H. P., Sheikh K. A., Lehmann H. C. Peripheral neuropathy: assessment of proximal nerve integrity by diffusion tensor imaging. Muscle Nerve. 2013;48:889-96. https://doi.org/10.1002/mus.23855</mixed-citation><mixed-citation xml:lang="en">Mathys C., Aissa J., Zu Hörste G. M., Reichelt D. C., Antoch G., Turowski B., Hartung H. P., Sheikh K. A., Lehmann H. C. Peripheral neuropathy: assessment of proximal nerve integrity by diffusion tensor imaging. Muscle Nerve. 2013;48:889-96. https://doi.org/10.1002/mus.23855</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Matsumoto H., Konoma Y., Shimizu T. Okabe S., Shirota Y., Hanajima R., Terao Y., Ugawa Y. Aging influences central motor conduction less than peripheral motor conduction: a transcranial magnetic stimu - lation study. Muscle Nerve. 2012;46:932- 936. https://doi.org/10.1002/mus.23430</mixed-citation><mixed-citation xml:lang="en">Matsumoto H., Konoma Y., Shimizu T. Okabe S., Shirota Y., Hanajima R., Terao Y., Ugawa Y. Aging influences central motor conduction less than peripheral motor conduction: a transcranial magnetic stimu - lation study. Muscle Nerve. 2012;46:932-936. https://doi.org/10.1002/mus.23430</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Moriyama H., Amano K., Itoh M., Shimada K, Otsuka N. Morphometric aspects of peripheral nerves in adults and the elderly. J. Peripher. Nerv. Syst. 2007;12(3):205- 209. https://doi.org/10.1111/j.1529-8027.2007.00140.x</mixed-citation><mixed-citation xml:lang="en">Moriyama H., Amano K., Itoh M., Shimada K, Otsuka N. Morphometric aspects of peripheral nerves in adults and the elderly. J. Peripher. Nerv. Syst. 2007;12(3):205- 209. https://doi.org/10.1111/j.1529-8027.2007.00140.x</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Oudeman J., Verhamme C., Engbersen M. P., Caan M. W. A., Maas M., Froeling M., Nederveen A. J., Strijkers G. J. Diffusion tensor MRI of the healthy brachial plexus. PLoS One. 2018;9;13(5):e0196975. https://doi.org/10.1371/journal.рone.0196975</mixed-citation><mixed-citation xml:lang="en">Oudeman J., Verhamme C., Engbersen M. P., Caan M. W. A., Maas M., Froeling M., Nederveen A. J., Strijkers G. J. Diffusion tensor MRI of the healthy brachial plexus. PLoS One. 2018;9;13(5):e0196975. https://doi.org/10.1371/journal.рone.0196975.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Padua L., Hobson-Webb L. D. Ultrasound as the first choice for peripheral nerve imaging? Neurology. 2013;80:1626-7. https://doi.org/10.1212/WNL.0b013e3182905017</mixed-citation><mixed-citation xml:lang="en">Padua L., Hobson-Webb L. D. Ultrasound as the first choice for peripheral nerve imaging? Neurology. 2013;80:1626-7. https://doi.org/10.1212/WNL.0b013e3182905017</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pfefferbaum A., Sullivan E. V. Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming. Magn. Reson. Med. 2003;49(5):953-61. https://doi.org/10.1002/mrm.10452</mixed-citation><mixed-citation xml:lang="en">Pfefferbaum A., Sullivan E. V. Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming. Magn. Reson. Med. 2003;49(5):953-61. https://doi.org/10.1002/mrm.10452</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Su X., Kong X., Liu D., Kong X., Alwalid O., Wang J., Shu S., Zheng C. Multimodal magnetic resonance imaging of peripheral nerves: Establishment and validation of brachial and lumbosacral plexi measurements in 163 healthy subjects. Eur. J. Radiol. 2019;117:41-48. https://doi.org/10.1016/j.ejrad.2019.05.017</mixed-citation><mixed-citation xml:lang="en">Su X., Kong X., Liu D., Kong X., Alwalid O., Wang J., Shu S., Zheng C. Multimodal magnetic resonance imaging of peripheral nerves: Establishment and validation of brachial and lumbosacral plexi measurements in 163 healthy subjects. Eur. J. Radiol. 2019;117:41-48. https://doi.org/10.1016/j.ejrad.2019.05.017</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Tagliafico A., Calabrese M., Puntoni M., Pace D., Baio G., Neumaier C. E., Martinoli C. Brachial plexus MR imaging: accuracy and reproducibility of DTI-derived measurements and fibre tractography at 3.0-T. Eur. Radiol. 2011;21(8):1764-71. https://doi.org/10.1007/s00330-011-2100-z</mixed-citation><mixed-citation xml:lang="en">Tagliafico A., Calabrese M., Puntoni M., Pace D., Baio G., Neumaier C. E., Martinoli C. Brachial plexus MR imaging: accuracy and reproducibility of DTI-derived measurements and fibre tractography at 3.0-T. Eur. Radiol. 2011;21(8):1764-71. https://doi.org/10.1007/s00330-011-2100-z</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Takagi T., Nakamura M., Yamada M., Hikishima K., Momoshima S., Fujiyoshi K., Shibata S., Okano H. J., Toyama Y., Okano H. Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography. Neuroimage. Elsevier Inc. 2009; 44(3):884-892. https://doi.org/10.1016/j.neuroimage.2008.09.022</mixed-citation><mixed-citation xml:lang="en">Takagi T., Nakamura M., Yamada M., Hikishima K., Momoshima S., Fujiyoshi K., Shibata S., Okano H. J., Toyama Y., Okano H. Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography. Neuroimage. Elsevier Inc. 2009; 44(3):884-892. https://doi.org/10.1016/j.neuroimage.2008.09.022</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tanitame K., Iwakado Y., Akiyama Y., Ueno H., Ochi K., Otani K., Takasu M., Date S., Awai K. Effect of age on the fractional anisotropy (FA) value of peripheral nerves and clinical significance of the agecorrected FA value for evaluating polyneuropathies. Neuroradiology. 2012;54(8): 815-21. https://doi.org/10.1007/s00234-011-0981-9</mixed-citation><mixed-citation xml:lang="en">Tanitame K., Iwakado Y., Akiyama Y., Ueno H., Ochi K., Otani K., Takasu M., Date S., Awai K. Effect of age on the fractional anisotropy (FA) value of peripheral nerves and clinical significance of the agecorrected FA value for evaluating polyneuropathies. Neuroradiology. 2012;54(8): 815-21. https://doi.org/10.1007/s00234-011-0981-9</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ugrenović S., Jovanović I., Vasović L., Kundalić B., Čukuranović R., Stefanović V. Morphometric analysis of the diameter and g-ratio of the myelinated nerve fibers of the human sciatic nerve during the aging process. Anat. Sci. Int. 2016;91(3): 238-245. https://doi.org/10.1007/s12565-015-0287-9</mixed-citation><mixed-citation xml:lang="en">Ugrenović S., Jovanović I., Vasović L., Kundalić B., Čukuranović R., Stefanović V. Morphometric analysis of the diameter and g-ratio of the myelinated nerve fibers of the human sciatic nerve during the aging process. Anat. Sci. Int. 2016;91(3): 238-245. https://doi.org/10.1007/s12565-015-0287-9</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Van Hecke W., Leemans A., Sijbers J., Vandervliet E., Van Goethem J., Parizel P. M. A tracking-based diffusion tensor imaging segmentation method for the detection of diffusion-related changes of the cervical spinal cord with aging. J. Magn. Reson. Imaging. 2008;27(5):978- 91. https://doi.org/10.1002/jmri.21338</mixed-citation><mixed-citation xml:lang="en">Van Hecke W., Leemans A., Sijbers J., Vandervliet E., Van Goethem J., Parizel P. M. A tracking-based diffusion tensor imaging segmentation method for the detection of diffusion-related changes of the cervical spinal cord with aging. J. Magn. Reson. Imaging. 2008;27(5):978- 91. https://doi.org/10.1002/jmri.21338</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Van den Bergh P. Y. K., van Doorn P. A., Hadden R. D. M., Avau B., Vankrunkelsven P., Allen J. A., Attarian S., BlomkwistMarkens P. H., Cornblath D. R., Eftimov F., Goedee H. S., Harbo T., Kuwabara S., Lewis R. A., Lunn M. P., Nobile-Orazio E., Querol L., Rajabally Y. A., Sommer C., Topaloglu H. A. European Academy of Neurology / Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force — Second revision. J. Peripher. Nerv. Syst. 2021;26(3):242-268. https://doi.org/10.1111/jns.12455</mixed-citation><mixed-citation xml:lang="en">Van den Bergh P. Y. K., van Doorn P. A., Hadden R. D. M., Avau B., Vankrunkelsven P., Allen J. A., Attarian S., BlomkwistMarkens P. H., Cornblath D. R., Eftimov F., Goedee H. S., Harbo T., Kuwabara S., Lewis R. A., Lunn M. P., Nobile-Orazio E., Querol L., Rajabally Y. A., Sommer C., Topaloglu H. A. European Academy of Neurology / Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force — Second revision. J. Peripher. Nerv. Syst. 2021;26(3):242-268. https://doi.org/10.1111/jns.12455</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Vargas M., Gariani J., Delattre B., Dietemann J-L., Lovblad K., Becker M. Three-Dimensional MR Imaging of the Brachial Plexus. Semin Musculoskelet Radiol. 2015;19(2):137-148. https://doi.org/10.1055/s-0035-1546300</mixed-citation><mixed-citation xml:lang="en">Vargas M., Gariani J., Delattre B., Dietemann J-L., Lovblad K., Becker M. Three-Dimensional MR Imaging of the Brachial Plexus. Semin Musculoskelet Radiol. 2015;19(2):137-148. https://doi.org/10.1055/s-0035-1546300</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wade R. G., Whittam A., Teh I., Andersson G., Yeh F. C., Wiberg M., Bourke G. Diffusion tensor imaging of the roots of the brachial plexus: a systematic review and meta-analysis of normative values. Clin. Transl. Imaging. 2020;8(6):419-431. https://doi.org/10.1007/s40336-020-00393-x</mixed-citation><mixed-citation xml:lang="en">Wade R. G., Whittam A., Teh I., Andersson G., Yeh F. C., Wiberg M., Bourke G. Diffusion tensor imaging of the roots of the brachial plexus: a systematic review and meta-analysis of normative values. Clin. Transl. Imaging. 2020;8(6):419-431. https://doi.org/10.1007/s40336-020-00393-x</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Wade R. G., Teh I., Andersson G., Yeh F. C., Wiberg M., Bourke G. Fractional anisotropy thresholding for deterministic tractography of the roots of the brachial plexus. Sci. Rep. 2021;11(1):80. https://doi.org/10.1038/s41598-020-79840-8</mixed-citation><mixed-citation xml:lang="en">Wade R. G., Teh I., Andersson G., Yeh F. C., Wiberg M., Bourke G. Fractional anisotropy thresholding for deterministic tractography of the roots of the brachial plexus. Sci. Rep. 2021;11(1):80. https://doi.org/10.1038/s41598-020-79840-8</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
