Non-Invasive Technique for MRI Diagnostics of Bone Marrow Cellularity in Children with Acute Lymphoblastic Leukemia
https://doi.org/10.52560/2713-0118-2023-5-9-19
Abstract
Evaluation of the apparent fat fraction (FF) changes in patients at different stages of leukemia treatment compared with children without hematological disorders. The study included 24 healthy volunteers (control group), 40 patients with leukemia: 20 in the acute phase of the disease and 20 patients after chemotherapy in hematopoietic aplasia. Four regions of interest were chosen in size of 150 mm2: in the body of the right and left iliac bones, as well as in the bodies of L4 and L5 vertebras. FF significantly changes in patients with leukemia regarding the control group. Quantitative MRI images is a new method for assessing changes in the bone marrow of children with leukemia.
Supporting agencies: The article was funded under the grant of the Russian Science Foundation No. 22-25-00553 «New MRI technologies in the study of tissue characteristics of the bone marrow in aplastic anemia: the possibility of monitoring the effectiveness of therapy and comparison with the results of histopathomorphology.»
About the Authors
G. V. Tereshchenko
Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
Tereshchenko Galina Viktorovna, Ph. D., Senior Researcher and Head of Radiology department
1, ul. Samory Mashela, Moscow, 117997
+7 (495) 287-65-70 (add. 1220)
N. A. Kriventsova
Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
Russian Federation
Russian Federation
Kriventsova Nataliya Alekseevna, Research Laboratory Assistant, Radiologist of Radiology department
1, ul. Samory Mashela, Moscow, 117997
+7 (495) 287-65-70 (add. 4518)
D. A. Kupriyanov
Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
Kupriyanov Dmitriy Alekseevich, Ph. D., Senior Researcher of Radiology department
1, ul. Samory Mashela, Moscow, 117997
+7 (495) 287-65-70 (add. 1221)
D. V. Litvinov
Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
Litvinov Dmitriy Vital’evich, Ph. D., Head Physician
1, ul. Samory Mashela, Moscow, 117997
+7 (495) 287-65-70 (add. 6106)
G. A. Novichkova
Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
Novichkova Galina Anatol’evna, М. D., General Director
1, ul. Samory Mashela, Moscow, 117997
+7 (495) 287-65-70 (add. 6106)
References
1. Kaprin A. D., Starinsky V. V., Petrova G. V. Malignant neoplasms in Russia in 2017. Moscow. 2018. (In Russ.).
2. Kriventsova N. A., Kupriyanov D. A., Men’shchikov P. E. et al. MR-biomarker of bone marrow in children with acute lymphoblast leukemia. REJR. 2020; 10(4):159-168. (In Russ.).
3. Kriventsova N. A., Tereshchenko G. V. Bone marrow cellularity assessment using magnetic resonance imaging in children with aplastic anemia. Pediatric Hematology/Oncology and Immunopathology. 2023;22(1):73-77. (In Russ.).
4. Solovieva A. A., Yatsyk G. A., Ponomarev R. V. et al. Patent: Quantification of Specific Bone Marrow Infiltration in Gaucher Disease Using the Dixon Method. 2018. (In Russ.).
5. Aparisi Gómez M. P.; Ayuso Benavent C., Simoni P. et al. Fat and bone: the multiperspective analysis of a close relation ship. Quantitative Imaging in Medicine and Surgery. 2020;10(8);1614-1635.
6. Baum T., Rohrmeier A., Syväri J. et al. Anatomical Variation of Age-Related Changes in Vertebral Bone Marrow Composition Using Chemical Shift EncodingBased Water–Fat Magnetic Resonance Imaging. Frontiers in Endocrinology. 2018;9(Apr);141.
7. Chan B. Y., Gill K. G., Rebsamen S. L. et al. MR Imaging of Pediatric Bone Marrow. Radiographics. 2016;36(6):19111930.
8. Donners R., Obmann M. M., Boll D. et al. Dixon or DWI — Comparing the utility of fat fraction and apparent diffusion coefficient to distinguish between malignant and acute osteoporotic vertebral fractures. European Journal of Radiology. 2020;132.
9. Kriventsova N., Shestopalov A., Tereshchenko G. Bone Marrow Adipocytes and Hematology: A Literature Review. Journal of Biomedicine. 2021;11(2);123-130.
10. Lee S. H., Yoo H. J., Yu S. M. et al. Fat quantification in the vertebral body: Comparison of modified dixon technique with single-voxel magnetic resonance spect roscopy. Korean Journal of Radiology. 2019;20(1);126-133.
11. Whitehead T. P., Metayer C., Wiemels J. L. et al. Childhood Leukemia and Primary Prevention. Curr Probl Pediatr Adolesc Health Care. 2016;46(10);317352.
12. Xiang P., Wu X., Zeng Z. et al. Quantitative analysis of pelvic bone marrow fat using an MRI-based machine learning method for distinguishing aplastic anaemia from myelodysplastic syndromes. Clinical Radiology. 2023;78(6);e463-e468.
13. Aparisi Gómez M. P., Ayuso Benavent C., Simoni P. et al. Imaging of Bone Marrow: From Science to Practice. Seminars in Musculoskeletal Radiology. 2022;26(4);396-411.
14. Davis A. S., Viera A. J., Mead M. D. Leukemia: an overview for primary care. Am Fam Physician. 2014;89(9);731-738.
15. Habibi M. R., Hasanzadeh Kiabi F., Soleimani A. et al. Sedation and analgesia during bone marrow aspiration in children: Is ketamine and propofol combina tion (Ketofol) an appropriate agent? Indian J. Med. Paediatr. Oncol. 2013; 34(4);337-339.
16. Ruschke S., Pokorney A., Baum T. et al. Measurement of vertebral bone marrow proton density fat fraction in children using quantitative water-fat MRI. Magnetic Resonance Materials in Physics Biology and Medicine. 2017;30(5);449460.
Review
For citations:
Tereshchenko G.V., Kriventsova N.A., Kupriyanov D.A., Litvinov D.V., Novichkova G.A. Non-Invasive Technique for MRI Diagnostics of Bone Marrow Cellularity in Children with Acute Lymphoblastic Leukemia. Radiology - Practice. 2023;(5):9-19. (In Russ.) https://doi.org/10.52560/2713-0118-2023-5-9-19
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