Assessment of the Status of Resection Margins in Patients with Breast Cancer During Breast-Conserving Surgery Using Intraoperative Mammography
Ya. I. Bondarchuk,
S. S. Bagnenko,
A. V. Chernaya,
P. V. Krivorot’ko,
A. S. Artemyeva,
E. K. Zhiltsova,
N. Amirov https://doi.org/10.52560/2713-0118-2023-4-71-81
Abstract
The results of surgical treatment of 56 patients were analyzed. All patients were undergone on breast-conserving surgery with intraoperative X-ray control on a mammographic digital device.
The mean time to complete the study was 10 minutes, which did not significantly affect the duration of the operation.
Of the 56 studied preparations after breast-conserving surgery, a positive resection margin (R1) was found in 1 case during a planned histological examination, which is associated with a high X-ray density of the patient’s breast tissue. In 2 cases, positive resection margins (DCIS) were detected, additional excision made it possible to avoid repeated surgical intervention. In 1 case, a false positive result was obtained, which did not negatively affect the results of surgical treatment. There were no false negative results.
About the Authors
Ya. I. Bondarchuk
Federal National Medical Research Center of Oncology named after N. N. Petrov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Bondarchuk Yana Igorevna, Research Fellow, Breast Tumors Department
68, ul. Leningradskaya, Pesochny, Saint Petersburg, 197758
+7 (812) 439-95-55
S. S. Bagnenko
Federal National Medical Research Center of Oncology named after N. N. Petrov» of the Ministry of Health of the Russian Federation; Federal State Budgetary Educational Institution «St. Petersburg State Pediatric Medical University» of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
Bagnenko Sergey Sergeevich, M. D. Med., Associate Professor, Deputy Director, Head of the Scientific Department, Leading Researcher of the Scientific Department of Diagnostic and Interventional Radiology; Professor of the Department of Modern Methods of Diagnosis and Radiobeagion Therapy
68, ul. Leningradskaya, Pesochny, Saint Petersburg, 197758
+7 (812) 439-95-55
A. V. Chernaya
Federal National Medical Research Center of Oncology named after N. N. Petrov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Chernaya Antonina Viktorovna, Ph. D. Med., Radiologist, Senior Researcher, Scientific Department of Diagnostic and Interventional Radiology
68, ul. Leningradskaya, Pesochny, Saint Petersburg, 197758
+7 (812) 439-95-55
P. V. Krivorot’ko
Federal National Medical Research Center of Oncology named after N. N. Petrov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Krivorot’ko Petr Vladimirovich, M. D. Med., Professor, Head of the Surgical Department of Breast Tumors, Leading researcher
68, ul. Leningradskaya, Pesochny, Saint Petersburg, 197758
+7 (812) 439-95-55
A. S. Artemyeva
Federal National Medical Research Center of Oncology named after N. N. Petrov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Artemyeva Anna Sergeevna, Ph. D. Med., Head of the Scientific Laboratory of Tumor Morphology, Head of the Pathology Department
68, ul. Leningradskaya, Pesochny, Saint Petersburg, 197758
+7 (812) 439-95-55
E. K. Zhiltsova
Federal National Medical Research Center of Oncology named after N. N. Petrov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Zhiltsova Elena Konstantinovna, Ph. D. Med., Oncologist of the Department of breast Tumors
68, ul. Leningradskaya, Pesochny, Saint Petersburg, 197758
+7 (812) 439-95-55
N. Amirov
Federal National Medical Research Center of Oncology named after N. N. Petrov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Amirov Nikolay, Research Fellow, Breast Tumors Department
68, ul. Leningradskaya, Pesochny, Saint Petersburg, 197758
+7 (812) 439-95-55
References
1. Kaprin A. D. Malignant neoplasms in Russia in 2021 (morbidity and mortality) / ed. A. D. Kaprina, V. V. Starinsky, A. O. Shakhzadova // Moscow: MNIOI im. P. A. Herzen — branch of the Federal State Budgetary Institution «NMIRC Radiology» of the Ministry of Health of Russia. 2021. P. 237. (In Russ.).
2. Letyagin V. P. The evolution of surgical treatment of breast cancer. Tumors of the female reproductive system. 2012. No. 1. P. 32–36. (In Russ.).
3. Semiglazov V. F. Control of surgical resection margins in breast-conserving surgery of breast cancer / V. F. Semiglazov, V. V. Semiglazov, K. S. Nikolaev et al. Oncosurgery. 2014. No. 1. P. 58–63. (In Russ.).
4. Funk A., Heil J., Harcos A. et al. Efficacy of intraoperative specimen ra-diography as margin assessment tool in breast conserving surgery. Breast cancer research and treatment. 2020. Vol. 179, no. 2. P. 425–433. DOI: 10.1007/s10549-019-05476-6
5. Houssami N., Macaskill P., Marinovich M. L. et al. The association of surgical margins and local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy: a meta-analysis. Ann. Surg. Oncol. 2014. Vol. 21, no. 3. P. 717–30.
6. Jin M., Kim J. Y., Kim T. H. et al. Intraoperative Specimen Mammography for Margin Assessment in Breast-Conserving Surgery. J. of Breast Cancer. 2019. Vol. 22, no. 4. P. 635–640. DOI:10.4048/jbc.2019.22.e58
7. Kuritzky A., Reyna C., McGuire K. P. et al. Evaluation of 2014 margin guidelines on re-excision and recurrence rates after breast-conserving surgery: A multiinstitution retrospective study. Breast. 2020. No. 51. P. 29–33. DOI: 10.1016/j.breast.2020.02.013
8. Li W., Li X. Development of intraoperative assessment of margins in breast conserving surgery: a narrative review. Gland Surg. 2022. Vol. 11, no. 1. P. 258–269. URL: DOI:10.21037/gs-21-652
9. Lin C., Wang Y., Chen L. et al. Specimen mammography for intraopera-tive margin assessment in breast conserving surgery: a meta-analysis. Scientific reports. 2022. Vol. 12, no. 1. P. 18440. DOI: 10.1038/s41598-022-23234-5
10. Man V. C., Cheung P. S. Neoadjuvant chemotherapy increases rates of breastconserving surgery in early operable breast cancer. Hong Kong Med. J. 2017. Vol. 23, no. 3. P. 251–257.URL: https://doi:10.12809/hkmj164972
11. Pataky R. E., Baliski C. R. Reoperation costs in attempted breast-conserving surgery: a decision analysis. Curr. Oncol. 2016. Vol. 23, no. 5. P. 314–321. DOI: 10.3747/co.23.2989
12. Sung H. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer / H. Sung, J. Ferlay, R. Siegel et al. J. Clin. 2021. Vol. 71, no. 3. P. 209–249.
13. Wilke L., Czechura T., Wang C. et al. Repeat surgery after breast conservation for the treatment of stage 0 to II breast carcinoma: a report from the National Cancer Data Base, 2004-2010. JAMA Surg. 2014. Vol. 149, no. 2. P. 1296–305. DOI: 10.1001/jamasurg.2014.926
Review
For citations:
Bondarchuk Ya.I., Bagnenko S.S., Chernaya A.V., Krivorot’ko P.V., Artemyeva A.S., Zhiltsova E.K., Amirov N. Assessment of the Status of Resection Margins in Patients with Breast Cancer During Breast-Conserving Surgery Using Intraoperative Mammography. Radiology - Practice. 2023;(4):71-81. (In Russ.) https://doi.org/10.52560/2713-0118-2023-4-71-81
Views:
320
Email this article 