Current State of MRI in Diagnostics of Neurotoxic Complications of Polychemotherapy in Children (Literature Review and Case Series)
https://doi.org/10.52560/2713-0118-2025-4-44-63
Abstract
Aim. Analysis of literature on the use of magnetic resonance imaging (MRI) in visualization of polychemotherapy-associated neurotoxic complications in pediatric oncology patients and demonstration of the capabilities of MRI based on our clinical cases.
Materials and Methods. The literature was obtained using PubMed, Google Scholar, and E-library databases. Search terms included chemotherapy in children and associated neurotoxic complications. Following the analysis of the obtained data, a secondary search was performed with additional search terms: imaging methods, specific neurotoxic conditions and chemotherapeutic agents. Cases of neurotoxic complications of polychemotherapy in three oncological patients are also presented.
Results. Based on the analysis of the literature and clinical cases, the main clinical features and common MRI patterns in pediatric patients with chemotherapy-induced neurotoxicity were identified.
Conclusion. A comprehensive approach to MRI and understanding the imaging features of neurotoxic changes are essential for early diagnosis and treatment initiation, which is crucial for ensuring the reversibility of neurotoxic damage. Further investigation of the capabilities of various pulse sequences in MRI are necessary, as well as developing of new imaging methods, implementing standardized neuroimaging protocols in the pediatric population and conducting multicenter clinical trials on these issues.
About the Authors
S. D. k. Hadieva
Federal State Budgetary Educational Institution of Higher Education «Russian University of Medicine» of The Ministry of Health of the Russian Federation; Russian Children's Clinical Hospital – the separate structural unit of the Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Hadiyeva Sakina Jamalatdin, Postgraduate student, Radiology department; Radiologist, Department of Diagnostic Radiology
Moscow
N. A. Sholokhova
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; Clinical Municipal Children Hospital St. Vladimir of the Department of Healthcare of Moscow
Russian Federation
Russian Federation
Sholokhova Nataliya Aleksandrovna, D. Sc. in Medicine, Professor, Department of Pediatric Radiology; Head, Department of Radiodiagnostics
Moscow
M. V. Polyanskaya
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation; Russian Children's Clinical Hospital – the separate structural unit of the Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Polyanskaya Mayya Vladimirovna, PhD in Medicine, Assistant, Department of Neurology, Neurosurgery, and Medical Genetics; Radiologist, Department of Diagnostic Radiology
Moscow
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Hadieva S.D., Sholokhova N.A., Polyanskaya M.V. Current State of MRI in Diagnostics of Neurotoxic Complications of Polychemotherapy in Children (Literature Review and Case Series). Radiology - Practice. 2025;(4):44-63. (In Russ.) https://doi.org/10.52560/2713-0118-2025-4-44-63
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