Radiological Diagnostics of Totally Necrotic Nephroblastomas
https://doi.org/10.52560/2713-0118-2025-5-11-19
Abstract
Aim. To determine the radiological semiotics of totally necrotic nephroblastoma.
Materialsand Methods. Thestudyincluded 12 patientswithtotallynecroticnephroblastoma who underwent contrast-enhanced MSCT after specific therapy. Fractional enhancement contrast values were measured at a random tumor site. Radiological diagnostic data and pathological anatomy were compared.
Results. The values of the contrast enhancement fraction were determined, which amounted to 0.026 (2.6 %) for the arterial phase and 0.121 (12.1 %) for the venous phase.
Conclusion. Totally necrotic nephroblastoma, both histologically and radiologically, have a homologous structure, do not significantly accumulate contrast agent, may have a capsule and septa.
About the Authors
V. A. Lopatina
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
Lopatina Vera Alekseevna, radiologist, Researcher of Department Radiation Diagnosis
Москва
A. M. Mitrofanova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russia
Mitrofanova Anna Mihajlovna, Pathologist at the Department of Pathological Anatomy
Москва
M. V. Teleshova
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russia
Teleshova Margarita Viktorovna, Pediatric Oncologist at the Clinical Oncology Department
Москва
G. V. Tereshchenko
The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russia
Tereshchenko Galina Viktorovna, Ph. D., radiologist, Senior Researcher and Head of Radiology department
Москва
References
1. Erginel B., Vural S., Akin M., Karadaǧ Ç. A., Sever N., Yildiz A., Tanik C., Demir A. A., Yanar Ö., Dokucu A. I. Wilms’ tumor: a 24-year retrospective study from a single center. Pediatric hematology and oncology. 2014;31(5):409-14. https://doi.org/10.319/08880018.2014.930767
2. Mergen M., Welter N., Furtwängler R., Melchior P., Vokuhl C., Gessler M., Meier C.-M.,Kager L., Schenk J.-P., Graf N. The impact of the route to diagnosis in nephroblastoma. Cancer medicine. 2024;13(10): e7226. https://doi.org/10.1002/cam4.7226
3. Middleton P., Banieghbal B., Pitcher R., Schubert P. Radiological response and histological findings in nephroblastoma: Is the any correlation? African Journal of Paediatric Surgery. 2020;17(3-4):39-44. https://doi.org/10.4103/ajps.AJPS_86_20
4. Nelson M. V., van den Heuvel-Eibrink M. M., Graf N., Dome J. S. New approaches to risk stratification for Wilms tumor. Current opinion in pediatrics. 2021; 33(1):40-48. https://doi.org/10.1097/MOP.0000000000000988
5. Nilave N., Nahid S., Karim S., Islam S., Morshed A. Correlation of CT Scan Response to Necrosis and Volume Changes With Histopathology in Children With Wilms’ Tumor. Journal of pediatric surgery. 2024;59(8):1515-8. https://doi.org/10.1016/j.jpedsurg.2024.02.026
6. Pastore G., Znaor A., Spreafico F., Graf N., Pritchard-Jones K., Steliarova-Foucher E. Malignant renal tumours incidence and survival in European children (1978– 1997): report from the Automated Childhood Cancer Information System project. Eur. J. Cancer. 2006;42(13):2103-14. https://doi.org/10.1016/j.ejca.2006.05.010
7. Rogers H. J., Verhagen M. V., Shelmerdine S. C., Clark C. A., Hales P. W. Analternative approach to contrast-enhanced imaging: diffusion-weighted imaging and T1weighted imaging identifies and quantifies necrosis in Wilms tumour. European Radiology. 2019;29(8):4141–9. https://doi.org/10.1007/s00330-018-5907-z
8. Vujanić G. M., Gessler M., Ooms A. H. G., Collini P., Coulomb-l’Hermine A., D’Hooghe E., de Krijger R. R., Perotti D., Pritchard-Jones K., Vokuhl C., van den Heuvel-Eibrink M. M., Graf N. The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nature reviews. Urology. 2018; 15(11):693–701. https://doi.org/10.1038/S41585-018-0100-3
Supplementary files
Review
For citations:
Lopatina V.A., Mitrofanova A.M., Teleshova M.V., Tereshchenko G.V. Radiological Diagnostics of Totally Necrotic Nephroblastomas. Radiology - Practice. 2025;(5):11-19. (In Russ.) https://doi.org/10.52560/2713-0118-2025-5-11-19
Views:
22
Email this article 