Capabilities of Magnetic Resonance Volumetry in Assessing the Response to Neoadjuvant Therapy of Primary Operable and Locally Advanced Breast Cancer

Abstract

The aim of the work was to analyze the significance of magnetic resonance volumetric measurement in assessing the response to neoadjuvant therapy for primary operable and locally advanced breast cancer (BC). The study included 77 patients aged 30 to 80 years, of which 40 (67,5 %) patients were with primary resectable and 37 (32,5 %) with locally advanced primary non-resectable ВС. When planning neoadjuvant therapy (NAT), the determining factors were the degree of malignancy (G) and proliferative activity (Ki-67) of the tumor, the level of expression of steroid receptors (estrogen — ER / progesterone — PR) and the HER2/neu protein. Completed from 4 to 6 courses of NAT. Their effectiveness was analyzed according to the data of multiparametric magnetic resonance imaging (mpMRI); changes in the tumor volume and its axial dimensions were taken into account. When comparing the sizes of tumors determined by the results of the analysis of the resection material and MRI, it was found that MR-volumetry has a higher sensitivity (Ac = 89,6; 95 % CI: 64,1–90,9) compared to the RECIST 1.1 criteria, taking into account the linear dimensions (Ac = 78,3; 95 % CI: 53,6–93,0).