Измеряемый коэффициент диффузии и стандартизированная величина поглощения 18F-фтордезоксиглюкозы: есть ли корреляция с критериями прогноза инвазивного рака молочной железы
Abstract
The purpose of this study is to evaluate the relationship between DWI or PET/CT and prognostic factors of breast tumor, such as Ki-67 and Nottingham prognostic index value. The relationship between the apparent diffusion coefficient (ADC) values, maximal standard uptake value (SUVmax), Ki-67 and NPI groups were evaluated. ADC values showed a negative correlation of moderate strength with Ki-67; the ADC mean values in different prognostic groups of the NPI were significantly different. There was no statistically significant relationship between the parameters of SUVmax, Ki-67 and the values of NPI. The performed study demonstrated the interrelation of ADC values with the prognostic criteria of NST, which suggests the possibility of using the ADC as a non-invasive marker of survival.
About the Authors
P. B. Gelezhe
Fellow of Research and Practical Centre of Medical Radiology of Moscow Healthcare Department
Russian Federation
Russian Federation
S. P. Morozov
Fellow of Research and Practical Centre of Medical Radiology of Moscow Healthcare Department
Russian Federation
Russian Federation
I. A. Trofimenko
Fellow of Research and Practical Centre of Medical Radiology of Moscow Healthcare Department
Russian Federation
Russian Federation
I. Ya. Vasil’Eva
(European Medical Center
Russian Federation
Russian Federation
References
1. Boellaard R., O’Doherty M., Weber W. FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 // Eur. J. Nuc. Med. and Mol. Imaging. 2010. № 37. P. 181-200.
2. Choi S., Chang Yu., Park H., Kim H. Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer // Br. J. Radiol. 2012. № 85. P. 474-479.
3. Hatakenaka M., Soeda H., Yabuuchi H., Matsuo Yu., Kamitani T., Oda Y. Apparent diffusion coefficients of breast tumors: clinical application // Magn. Reson. Med. Sci. 2008. № 7. P. 23-29.
4. Haybittle J., Blamey R., Elston C., Johnson J., Doyle P., Campbell F. A prognostic index in primary breast cancer // Brit. J. Cancer. 1982. V. 45. № 3. P. 361-366.
5. Ho K., Lin G., Wang J., Lai C., Chang C., Yen T. Correlation of apparent diffusion coefficients measured by 3T diffusion weighted MRI and SUV from FDG PET/CT in primary cervical cancer // Eur. J. Nuc. Med. and Mol. Imaging. 2009. № 36. P. 200-208.
6. Ikenaga N., Otomo N., Toyofuku A., Ueda Yu., Toyoda K., Hayashi T. et al. Standardized uptake values for breast carcinomas assessed by fluorodeoxyglucose-positron emission tomography correlate with prognostic factors // Am. J. Surg. 2007. № 73. P. 1151-1157.
7. Jeh S., Kim S., Kim H., Kang B., Jeong S., Yim H. Correlation of the apparent diffusion coefficient value and dynamic magnetic resonance imaging findings with prognostic factors in invasive ductal carcinoma // J. Magn. Reson. Imaging. 2011. № 33. P. 102-109.
8. Kim S., Cha E., Kim H., Kang B., Choi J., Jung J. Diffusion-weighted imaging of breast cancer: correlation of the apparent diffusion coefficient value with prognostic factors // J. Magn. Reson. Imaging. 2009. № 30. P. 615-620.
9. Nakajo M., Kajiya Yu., Kaneko T., Kaneko Y., Takasaki T., Tani A. FDG PET/CT and diffusion-weighted imaging for breast cancer: prognostic value of maximum standardized uptake values and apparent diffusion coefficient values of the primary lesion // Eur. J. Nuc. Med. and Mol. Imaging. 2010. № 37. P. 2011-2020.
10. Park M., Cha E., Kang B., Ihn Yu., Baik J. The role of diffusion-weighted imaging and the Apparent Diffusion Coefficient (ADC) values for breast tumors // Ko. J. Radiol. 2007. № 8. P. 390-396.
11. Rakha E., Reis-Filho J., Ellis I. Basal-like breast cancer: a critical review // J. Clin. Oncol. 2008. V. 20. № 26. P. 2568- 2581.
12. Rakha E., Soria D., Green A., Lemetre C., Powe D., Nolan C., Garibaldi J., Ball G., Ellis I. Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer // Brit. J. Cancer. 2014. № 110. P. 1688-1697.
13. Razek A., Gaballa G., Denewer A., Nada N. Invasive ductal carcinoma: correlation of apparent diffusion coefficient value with pathological prognostic factors // NMR Biomed. 2010. № 23. P. 619-623.
14. Ueda S., Tsuda H., Asakawa H., Shigekawa T., Fukatsu K., Kondo N., et al. Clinicopathological and prognostic relevance of uptake level using 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer // Jap. J. Clin. Oncol. 2008. № 38. P. 250-258.
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For citations:
Gelezhe P.B., Morozov S.P., Trofimenko I.A., Vasil’Eva I.Ya. . Radiology - Practice. 2018;(4):6-17. (In Russ.)
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