Quantitative Bone Scan with 99mTc-pyrophosphate to Assess the Severity of Joint Inflammation
Abstract
The purpose of this study is to evaluate the methodology for quantitative bone scan to assess the joint inflammation severity in different rheumatic diseases. The study included 300 people (164 patients with a diagnosed rheumatoid and psoriatic arthritis, ankylosing spondylitis, peripheral spondylitis, osteoarthritis,
chronic gouty arthritis and 136 control patients, including those with psoriasis without arthritis and chronic urinary infection). Bone scan was performed with sodium pyrophosphate labeled with 99mТс, three hours after its infusion. For each joint the radiopharma-ceutical accumulation ratio (AR) was calculated. For most of the joints are found statistically significant correlations of AR with clinical symptoms of the joint involvement, as well as the dynamics of AR values while changing clinical and laboratory disease activity. It is noted that in patients with active chronic urinary tract infections and skin psoriasis increase of radiotracer accumulation in joints was similar to those in peripheral spondylitis and psoriatic arthritis, respectively. Obtained data allows to conclude that the single-phase quantitative bone scan with labeled 99mТс pyrophosphate, is a promising technique for the quantification of inflammatory activity. This method may be used for an objective assessment of disease activity and changes the joint inflammation during treatment
About the Authors
Elena G. Prohorova
Main Clinical Hospital Ministry of Internal Affairs Russian Federation
Russian Federation
Russian Federation
Ph. D. Med., Head of Radioisotope Diagnostic Department, Radiologist
Evgeniy V. Zhilyaev
EMC
Russian Federation
Russian Federation
М. D. Med., Professor, Chief Physician EMC
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Review
For citations:
Prohorova E., Zhilyaev E. Quantitative Bone Scan with 99mTc-pyrophosphate to Assess the Severity of Joint Inflammation. Radiology - Practice. 2017;(2):34-46. (In Russ.)
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