Possibilities of Computed Tomography with a Perfusion Program in the Diagnosis of Pancreatic Adenocarcinoma

Abstract

The aim was to study the possibilities and compare the diagnostic efficiency of computed tomography performed according to the standard protocol and using a perfusion program in detecting pancreatic adenocarcinoma. The study included 94 (58,4 %) men and 67 (41,6 %) women aged from 28 to 96 years (71,8 ± 12,4 years) with pancreatic adenocarcinoma verified by histological examination. All patients underwent computed tomography of the abdominal organs according to the standard protocol and using a perfusion program. With the standard protocol, tumors appeared as a focus of reduced contrast agent accumulation in the pancreatic phase in 123 (76,4 %) patients, did not differ in density and intensity of contrast agent accumulation from the pancreatic parenchyma in all phases in 38 (23,6 %) patients. The diagnostic efficiency of the standard protocol in detecting pancreatic adenocarcinoma was as follows: sensitivity - 95,8 %, specificity - 98,7 %, diagnostic accuracy - 94,7 %. With perfusion computed tomography, the tumor could not be visualized only in 2 (1,2 %) of 161 patients, the diagnostic efficiency of the method was: sensitivity 98,7 %, specificity 99,3 %, diagnostic accuracy 99 %, was higher in comparison with standard protocol.