Magnetic Resonance Tomography in the Diagnosis of IgG4-Related Kidney Disease (Literature Review with Own Clinical Reviews)

IgG4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by the occurrence of tumor-like foci in different organs with a unique histological pattern. The kidney is a frequently affected organ with tubulointerstitial nephritis, the representative lesion of IgG4-RD. We describe a 57-year-old man with IgG4-related kidney disease in which relatively rapidly progressive nephropathy. MRI is an alternative for patients with renal function impairment and contraindication to contrast-enhanced CT. On T2-weighted images renal lesions are hypointense and hyperintensity on diffusion-weighted imaging at a high b value. A percutaneous renal biopsy revealed IgG4-related kidney disease. Prescribing of prednisolone 40 mg/day improved the renal function. A rapid response to corticosteroid therapy is a very important feature of IgG4-RD. When the patient was arbitrarily withdrawn glucocorticoids, a relapse with progression of renal dysfunction was observed.The clinical course of this case highlighted the importance of MRI imaging to facilitate the earliest diagnosis and effective therapeutic intervention.

IgG4-связанное заболевание, IgG4-связанное заболевание почек, (ДВ) МРТ, IgG4-Related Disease, IgG4-Related Kidney Disease, MRI, DWI, Treatment of IgG4-Related Kidney, Glucocorticosteroids

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