Predicting of Pathologic Response to Neoadjuvant Chemotherapy in Locally-advanced Gastric Cancer by Volumetric Computed Tomography
Abstract
This study's aim is to evaluate the accuracy of CT volumetry in terms of predicting response to NAC in locally advanced GC. Pre- and post-chemotherapy volume of the tumor were measured using a dedicated 3D software (GE AW Volumeshare 5) and compared to histopathologic assessment of response. In patients with good response median tumor volume decrease was 54% vs 21% in patients with poor response, р < 0,0001. CT volumetry with a cut-off 37 % of tumor volume reduction predicts good morphological response after 3 cycles oof neoadjuvant chemotherapy in locally advanced gastric cancer with an overall accuracy of 92 %.
About the Authors
A. O. Klimenko
Russian Medical Academy of Continuing Professional Education, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
V. E. Sinitsyn
Lomonosov Moscow State University
Russian Federation
Russian Federation
I. V. Shrainer
Pirogov's City Clinical Hospital №1, Moscow Healthcare Department
Russian Federation
Russian Federation
E. A. Mershina
Lomonosov Moscow State University
Russian Federation
Russian Federation
V. K. Lyadov
Russian Medical Academy of Continuing Professional Education, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
V. S. Petrovichev
Federal Center of Treatment and Rehabilitation Ministry of Healthcare of Russia
Russian Federation
Russian Federation
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Review
For citations:
Klimenko A.O., Sinitsyn V.E., Shrainer I.V., Mershina E.A., Lyadov V.K., Petrovichev V.S. Predicting of Pathologic Response to Neoadjuvant Chemotherapy in Locally-advanced Gastric Cancer by Volumetric Computed Tomography. Radiology - Practice. 2019;(3):20-28. (In Russ.)
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