The Ultrasonography Capabilities of Cerebrospinal Fluid Dynamics in Neonates (literature Review and Own Observations)
https://doi.org/10.52560/2713-0118-2026-3-73-87
Abstract
Objective. Investigate doppler sonographic capabilities in the assessment of cerebrospinal fluid flow dynamics in infants with central nervous system disorders.
Materials and Methods. The article presents data on physiology of synthesis and circulation of cerebrospinal fluid (CSF), its normal composition, and features in the neonatal period. Since the 1990 the doppler researches of cerebrospinal fluid dynamics has been analyzed.
Results. The variants of cerebrospinal fluid flow doppler imaging phenomenon in neonates are presented in color and pulse wave modes, furthermore the types of synchronization of the cerebrospinal fluid flow in various pathological conditions. The publication highlights the magnetic resonance imaging (MRI) results obtained in recent years in the study of cerebrospinal fluid dynamics, as well as experimental data on the use of doppler technologies in assessing fluid flows within catheters, including monitoring the functioning of ventriculoperitoneal shunts. Own doppler observations of studying phenomenon are demonstrated.
Conclusion. The Doppler study of cerebrospinal fluid flows has a certain diagnostic value in neonates with cerebral hemorrhage and inflammation; however, a number of controversial issues remain:
— the low detection rate of phenomenon is unclear in changes of cerebrospinal fluid rheological properties in intracranial hemorrhages and meningitis;
— various patterns of cerebrospinal fluid movement synchronization are not completely soluble;
— experimental data do not completely correspond to clinical experience, which determines the perspectives for further researches.
About the Authors
E. B. OlkhovaRussian Federation
Olkhova Elena Borisovna, M. D. Med., Professor, Professor of Department of Radiology, Federal State Budgetary Educational Institution of Higher Education «Russian University of Medicine» of the Ministry of Health of the Russian Federation (FSBEI HE «ROSUNIMED» of MOH of Russia); the Head of Department of the Ultrasound and Functional Diagnostic St. Vladimir Children's Moscow Clinical Hospital, Moscow of Healthcare Department
Moscow
A. G. Shandra
Russian Federation
Shandra Anna Gennadievna, Radiologist of Department of Ultrasound and Functional Diagnostic
Moscow
References
1. Afandiev R. M., Fadeeva L. M., Solo zhentseva K. D., Pronin I. N. Magnetic Resonance Imaging in the Evaluation of Hydrocephalus. Journal of radiology and nuclear medicine. 2021;102(2):124-133. (In Russ.). DOI
2. Vasin R. A., Madrahimov M. T., Shejkin M. O. Gidrodinamicheskaja Model, Simuli rujuwaja Izmenenie Haraktera Sinhroniza cii Likvorodinamiki u Novorozhdennyh. Gidravlicheskie i teplotehnicheskie sistemy i agregaty: Sbornik trudov XXIX Mezhdunarodnoj nauchno-tehnicheskoj konferen cii (Moskva, 10 dekabrja 2025 g.). Moskva: OOO «Izdatel'stvo "Mir nauki"», 2025. S. 87– 92. (In Russ.). DOI
3. Vlasuk V. V. Patologija Golovnogo Mozga u Novorozhdjonnyh i Detej Rannego Vozrasta. М.: Logosfera, 2014. 288 s.: il. ISBN 978-5- 98657-050-1. (In Russ.).
4. Olchova E. B. Cerebrospinal Fluid Flow Jet as the Echographic Phenomenon in New born. Ultrasound and Functional Diagnostics. 2006;5:65-75. (In Russ.). EDN JXZSVN.
5. Olchova E. B., Vasin R. A., Shandra A. G., Krasnikov M. A. Cerebrospinal Fluid Flow Jet Phenomenon as a Mark of Intracranial Pressure in an Infant with Intraventricular He morrhage. Clinical Observation. Radiology — Practice. 2025;(4):101-110. (In Russ.). DOI
6. Slynko I. I., Nekhlopochin A. S. Cerebrospinal Fluid Flow. Part 1. Classical Theory and Its Evolution. Ukrainian Neurosurgical Journal. 2018;(3):15-23. (In Russ.). DOI
7. Tokarev A. S., Talypova D. A., Terekhin I. A., Grin A. A. Quantitative and Qualitative Analysis of CSF Flow Dynamics. Russian Sklifosovsky Journal «Emergency Medical Care». 2022;11(1):86-95. (In Russ.). DOI
8. Aktas G., Kollmeier J. M., Joseph A. A., Merboldt K. D., Ludwig H. C., Gärtner J., Frahm J., Dreha-Kulaczewski S. Spinal CSF flow in response to forced thoracic and abdominal respiration. Fluids Barriers CNS. 2019;16(1):10. DOI
9. Aslanidis T., Lutsenko O., Kato Y., Kolarovszki B., Zhao G. Cerebral Hemo dynamics in Pediatric Hydrocephalus: Eva luation by Means of Transcranial Doppler Sonography. In the book by: Theodoros As lanidis. Highlights on Hemodynamics. 2018. 88 p. ISBN 978-1-78923-794-8. DOI
10. Bektaşoğlu P. K., Gürer B. History, Anatomy, Histology and Embryology of the Ventricles and Physiology of the Cerebrospinal Fluid. In the book: Cerebrospinal Fluid. 2021. 182 p. ISBN 978-1-83969-695-4. DOI
11. Bradley W. G. Jr. Magnetic Resonance Ima ging of Normal Pressure Hydrocephalus. Semin Ultrasound CT MR. 2016;37(2):120- 128. DOI
12. Brasil S., Patriota G. C., Godoy D. A., Pa ranhos J. L., Rubiano A. M., Paiva W. S. Monro-Kellie 4.0: moving from intracranial pressure to intracranial dynamics. Crit Care. 2025;29:229. DOI
13. Brinker T., Stopa E., Morrison J., Klinge P. A new look at cerebrospinal fluid circulation. Fluids Barriers CNS. 2014;11:10. DOI
14. Brock R. S., Taricco M. A., de Oliveira M. F., de Lima Oliveira M., Teixeira M. J., BorSeng-Shu E. Intraoperative Ultrasonography for Definition of Less Invasive Surgical Technique in Patients with Chiari Type I Malformation. World Neurosurg. May 2017; 101:466–475. DOI
15. García-González O., Mireles-Cano J. N., Silva-Cerecedo P., Rueda-Franco F. The aqueduct. Child's Nerv. Syst. 2014;30(7): 1147-1149. DOI
16. Gomella T., Cunningham M., Eyal F. G., Tuttle D. J. Hydrocephalus and Ventriculomegaly. Neonatology: Management, Procedures, OnCall Problems, Diseases, and Drugs. 2013. McGraw-Hill Education, 7e. Text: electronic. Transformational platform [website]. URL (date of application: 10/11/2025). ISBN 13: 978-0071768016.
17. Han G., Jiao B., Zhang Y., Wang Z., Liang C., Li Y., Hsu Y. C., Bai R. Arterial pulsation dependence of perivascular cerebrospinal fluid flow measured by dynamic diffusion tensor imaging in the human brain. Neuroimage. 2024;297:120653. DOI
18. Hartman R., Aglyamov S., Fox D. J. Jr, Eme lianov S. Quantitative contrast-enhanced ultrasound measurement of cerebrospinal fluid flow for the diagnosis of ventricular shunt mal function. J. Neurosurg. 2015;123(6):1420-6.DOI
19. Hwang M., Tierradentro-García L. O., Ko zak B. L., Darge K. Cerebrospinal Fluid Flow Detection in Post-hemorrhagic Hyd rocephalus with Novel Microvascular Ima ging Modality. J. Ultrasound Med. 2022;41 (4):1013-1017. DOI
20. Kelley D. H., Thomas J. H. Cerebrospinal Fluid Flow. Annu. Rev. Fluid. Mech. 2023; 55:237-264. DOI
21. Kelly E. J., Yamada S. Cerebrospinal Fluid Flow Studies and Recent Advancements. Semin. Ultrasound CT MR. 2016;37(2):92-9. DOI
22. Lloyd R. A., Butler J. E., Gandevia S. C., Ball I. K., Toson B., Stoodley M. A., Bilston L. E. Respiratory cerebrospinal fluid flow is driven by the thoracic and lumbar spinal pressures. J. Physiol. 2020;598(24):5789- 5805. DOI
23. Mathew M., Jimoh A. O., Matthew L. M., Mezue W. C., Uche E. O., Igashi J., Mahmud M. R., Okpara S. E., Mathew M. B. Assessment of childhood intracranial pressure: a comparative study of transcranial Doppler ultrasound indices and findings at ventriculoperitoneal shunt. Child's Nerv. Syst. 2024;40(9):2915-2920. DOI
24. Park S., Yoon H., Emelianov S., Aglyamov S. Fluid flow measurement for diagnosis of ventricular shunt malfunction using nonlinear responses of microbubbles in the contrast-enhanced ultrasound imaging. Japn. J. Appl. Phys. 2017;56(7 Suppl 1):07JF10. DOI
25. Perkins A. C., Lawes S. C., Mitchell L. A., Jaspan T. A simple simulation for the vi sualisation of CSF flow in infants with hyd rocephalus. Ultrasound Med. Biol. 1994; 20(1):21-6. DOI
26. Putzer D., Brawanski K., Verius M., Ober herber H., Thome C., Gizewski E. R., Gru ber H. Noninvasive CSF shunt patency eva luation by superb microvascular imaging. Neurosurg. Rev. 2023 Aug 1;46(1):190. DOI
27. Takizawa K., Matsumae M., Hayashi N., Hirayama A., Sano F., Yatsushiro S., Kuroda K. The Choroid Plexus of the Lateral Ventricle As the Origin of CSF Pulsation Is Questionable. Neurol. Med. Chir (Tokyo). 2018;58(1):23-31. DOI
28. Tatsuno M., Hasegawa M., Iwasaki J., Saito Y. Color Doppler flow imaging of CSF flow in infants with intracranial hemorrhage. Brain Dev. 1993;15(5):333-9. DOI
29. Tierradentro-Garcia L. O., Onyango L., Den nis R., Freeman C. W., Haddad S., Kozak B., Hwang M. Evaluation of the Cerebrospinal Fluid Flow Dynamics with Microvascular Imaging Ultrasound in Infants. Children (Basel). 2023;10(2):245. DOI
30. Winkler P. Colour-coded echographic flow imaging and spectral analysis of cerebrospinal fluid (CSF) in infants. Part II. CSF-dynamics. Pediatr. Radiol. 1992;22(1):31-42. DOI
31. Yatsushiro S., Sunohara S., Tokushima T., Takizawa K., Matsumae M., Atsumi H., Horie T., Kajihara N., Kuroda K. Characterization of Cardiac and Respiratorydriven Cerebrospinal Fluid Motions Using a Correlation Mapping Technique Based on Asynchronous Two-dimensional Phase Contrast MR Imaging. Magn. Reson. Med. Sci. 2021;20(4):385-395. DOI
32. Yılmaz T. F., Aralasmak A., Toprak H., Mehdi E., Kocaman G., Kurtcan S., Kaya M. O., Alkan A. Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension. Radiol. Med. 2019;124(5):382-391. DOI
33. Zhang M., Hu X., Wang L. A Review of Cerebrospinal Fluid Circulation and the Pathogenesis of Congenital Hydrocephalus. Neurochem. Res. 2024;49(5):1123-1136. DOI
Supplementary files
|
1. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(5MB)
|
Indexing metadata ▾ | |
|
2. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(1MB)
|
Indexing metadata ▾ | |
|
3. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(427KB)
|
Indexing metadata ▾ | |
|
|
4. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(147KB)
|
Indexing metadata ▾ | |
|
|
5. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(12KB)
|
Indexing metadata ▾ | |
|
|
6. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(12KB)
|
Indexing metadata ▾ | |
|
|
7. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(10KB)
|
Indexing metadata ▾ | |
|
|
8. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(11KB)
|
Indexing metadata ▾ | |
|
|
9. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(15KB)
|
Indexing metadata ▾ | |
|
|
10. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(11KB)
|
Indexing metadata ▾ | |
|
|
11. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(25KB)
|
Indexing metadata ▾ | |
|
|
12. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(16KB)
|
Indexing metadata ▾ | |
|
|
13. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(21KB)
|
Indexing metadata ▾ | |
|
|
14. Неозаглавлен | |
| Subject | ||
| Type | Other | |
View
(13KB)
|
Indexing metadata ▾ | |
Review
For citations:
Olkhova E.B., Shandra A.G. The Ultrasonography Capabilities of Cerebrospinal Fluid Dynamics in Neonates (literature Review and Own Observations). Radiology - Practice. 2026;(3):73-87. (In Russ.) https://doi.org/10.52560/2713-0118-2026-3-73-87
JATS XML
















