11C-methionine and 18F- fluorodeoxyglucose Positron Emission Tomography in Noninvasive Differential Diagnosis of Anaplastic Astrocytoma and Glioblastoma

Purpose of the study is investigation of the possibilities of Positron Emission Tomography - Computed Tomography (PET-CT) with different radiopharmaceuticals in non-invasive differential diagnosis of primary high grade gliomas. 18 patients, 11 with glioblastoma (GB) and 7 with anaplastic astrocytoma (AA), were examined before surgery with magnetic resonance imaging (MRI) and PET-CT with 11С-methionine (MET) and 18F-fluorodeoxyglucose (FDG). The analysis was carried out according to the standardized uptake value (SUV) in the tumor and healthy brain tissue, and tumor to normal (T/N) ratio. AA and GB groups are significantly different in T/N ratio for 11C-MET (1,62 ± 0,71 in AA versus 3,97 ±1,04 in GB, p < 0,001), and for 18F-FDG (0,64 ± 0,11 in AA versus 1,25 ± 0,66 in GB, p = 0,02). Levels of accumulation of 11C-MET and 18F-FDG in intact brain tissue correlate with each other (value of R2 = 0,61). The areas of high accumulation of two radiopharmaceuticals in the tumor stroma do not coincide. Our study demonstrated that the accumulation of 18F-FDG and 11C-methionine in HGG significantly depends on tumor grade. To improve practical value of this study patients with anaplastic oligodendrogliomas (Gr III), which are metabolically similar to GB, must be added to the comparison group.

11С-метионин, 18F-ФДГ, 11C-methionine, 18F-fluorodeoxyglucose, Positron Emission Tomography, High Grade Gliomas, Anaplastic Astrocytoma, Glioblastoma

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