Diagnostic Capabilities of Single Photon Emission Computed Tomography/Computed Tomography in the Bone Metastatic Disease Detection in Patients with Breast Cancer and Prostate Cancer
Abstract
The aim of the study was to evaluate the additional contribution of single photon emission computed tomography/computed tomography (SPECT/CT), used in conjunction with planar bone scan (BS), in bone metastatic disease detection and its effect on the tactics of managing patients with breast cancer (BCa) and prostate cancer (PCa). The study included 1412 patients with established oncological diagnosis (BCa - 844 patients, BCa - 568 patients), to which «whole body» planar BS and SPECT/CT were performed. In all patients included in the study, the fact of bone metastatic disease was established by the results of additional imaging techniques and follow up. Bone metastatic disease was detected in 324 (23 %) patients and excluded in 1088 (77 %). SPECT/CT had higher diagnostic indices than planar BS. Sensitivity, specificity and accuracy of bone metastatic disease detection of planar BS were 91, 71, 76 %, of SPECT/CT, 97, 93, 94 % respectively. The additional use of SPECT/CT in the second stage after the planar BS in 337 (24 %) patients from the general group (n = 1412) led to a change in the results of the diagnostic test. The additional use of SPECT/CT in the second stage after the planar BS allows to change the results of the diagnostic test in the evaluation of bone metastatic disease in patients with BCa and PCa, which can significantly affect the management tactics of patients.
About the Authors
A. V. Leont’Ev
Moscow Research Oncology Institute named after P. A. Herzen - branch of National Medical Research Radiological Center, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
A. I. Khalimon
Moscow Research Oncology Institute named after P. A. Herzen - branch of National Medical Research Radiological Center, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
T. N. Lazutina
Moscow Research Oncology Institute named after P. A. Herzen - branch of National Medical Research Radiological Center, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
I. V. Pylova
Moscow Research Oncology Institute named after P. A. Herzen - branch of National Medical Research Radiological Center, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
M. N. Pheduleev
Moscow Research Oncology Institute named after P. A. Herzen - branch of National Medical Research Radiological Center, Ministry of Healthcare of Russia
Russian Federation
Russian Federation
M. T. Kuliev
Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
A. A. Kostin
«National Medical Radiological Research Center», Ministry of Healthcare of Russia
Russian Federation
Russian Federation
A. D. Kaprin
«National Medical Radiological Research Center», Ministry of Healthcare of Russia
Russian Federation
Russian Federation
References
1. Каприн А. Д., Старинский В. В., Петрова Г. В. Злокачественные новообразования в России в 2014 году (заболеваемость и смертность). М., 2016. 250 с.
2. Каприн А. Д., Старинский В. В., Петрова Г. В. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). М., 2017. 250 с.
3. Коган М. И., Лоран О. Б., Петров С. Б. Радикальная хирургия рака предстательной железы. М.: ГЭОТАР-Медиа, 2006. 352 с.
4. Хурсевич Н. А., Слонимская Е. М., Усынин Е. А., Юрмазов З. А. Оценка распространенности процесса и выбор тактики лечения при раке предстательной железы с учетом факторов прогноза // Сибирский онкологический журнал. 2003. № 3. С. 60-61.
5. Манзюк Л. В., Снеговой А. В., Османова Л. И. Зомета в лечении костных метастазов и нарушений минерального обмена у онкологических больных // Русский медицинский журнал. 2007. № 25. 1924-1931с.
6. Fogelman I., Gnanasegaran G., van der Wall H. Radionuclideand hybrid bone imaging. Berlin; Heidelberg: Springer-Verlag, 2012. P. 666-667.
Review
For citations:
Leont’Ev A.V., Khalimon A.I., Lazutina T.N., Pylova I.V., Pheduleev M.N., Kuliev M.T., Kostin A.A., Kaprin A.D. Diagnostic Capabilities of Single Photon Emission Computed Tomography/Computed Tomography in the Bone Metastatic Disease Detection in Patients with Breast Cancer and Prostate Cancer. Radiology - Practice. 2018;(4):31-40. (In Russ.)
Views:
286
Email this article 