ORIGINAL RESEARCH
The aim of this work is to analyze quantitative data of magnetic resonance ASL-perfusion of the liver at admission and follow up of patients with viral cirrhosis.
The study included 34 patients with viral liver cirrhosis: 23 (67.6 %) men and 11 (32.4 %) women. All subjects underwent abdominal ultrasound with Dopplerography of the abdominal vessels, shear wave elastography, Arterial spin Labeling (ASL) — Perfusion of the liver by magnetic resonance imaging. Post-processing of ASL-perfusion images was carried out, their quantitative assessment in regenerative liver nodules and the parenchyma structure was carried out. It was found that for patients with liver cirrhosis according to Child-Pugh Class A, regardless of the degree of activity, the values of ASL-perfusion of the liver were 99.6 ± 1.8 ml/100g/min, with class B — 95.6 ± 4.9 ml/100g/min, with class C — 98.5 ± 2.6 ml/100g/min. To determine the diagnostic significance of liver ASL-perfusion, a generalized prognosis ratio ΔM = MNBF/ MHBF was calculated, where MNBF is a quantitative indicator of volumetric blood flow in the regenerative nodule, MHBF is a quantitative indicator of volumetric hepatic blood flow in the surrounding parenchyma. The results obtained by ASL-perfusion were compared with the data of shear wave elastography.
For patients with viral liver cirrhosis the quantitative indicator of ASL-perfusion of the liver is less than 101.4 ml/100g/min. To predict the course of viral etiology cirrhosis, the prognosis ratio ΔM should be taken, and if ΔM > 1, this indicates a poor prognosis (fibrosis progression), if ΔM ≤ 1 — a favorable one (no fibrosis progression). Diagnostic and prognostic significance of ASL-liver perfusion for patients with viral cirrhosis at admission to the hospital — AUROC = 0.865 (95 % CI 0.843–0.928) and follow up — AUROC = 0.915 (95 % CI 0.881–0.946).
CONTINUING MEDICAL EDUCATION
Syndromes of I and II gill arches called maxillofacial dysostoses are accompanied by damage of temporomandibular joint (TMJ). Craniofacial microsomia is one of the of maxillofacial dysostoses. This syndrome has a number of features associated with clinical manifestations which should be taken into account at steps of the diagnosis and treatment of such patients. The degree of mandibular hypoplasia in this pathology can vary from 0 to 3, and it is inversely proportional to the integrity of the articular disc on the side of the lesion. An increased mechanical load on a healthy joint leads to its dysfunction and dislocation of the articular disc at the healthy side. In addition to hypoplasia of bone structures, craniofacial microsomia is accompanied by subatrophy of masticatory muscles and that in couple leads to malocclusion and myodynamic imbalance. Before drawing up a treatment plan it is necessary to study the state of the TMJ on both sides using multislice computed tomography (MSCT) and magnetic resonance imaging (MRI). The approach to treatment should be individual, combined, staged, based on the severity of the symptom complex.
This article presents a review of foreign literature on the methods of diagnostics imaging of postoperative complications in orthognathic surgery. After the analysis, it can be argued that high-tech methods, such as computed tomography, cone beam computed tomography have improved the possibilities of imaging diagnostics in obtaining clinically significant information about postoperative complications of the maxillofacial region. Nevertheless, it should be noted that foreign sources not cover such issues as: tomographic semiotics of postoperative complications in orthognatic surgery, the role and place of radiation technologies in the examination of patients with postoperative complications; don`t specified indications and contraindications for use of each methods.
Massive splenic infarction (SI) is an extremely rare disease in childhood, the genesis of which is not always clear. Most often in children, SI develops against the background of oncohematological (in particular, myeloid leukemia), hematological (sickle cell anemia) and infectious (malaria, mononucleosis, cytomegalovirus infection) diseases and is small in size. Two own observations are presented, unique in the absence of a clear cause of SI and the massiveness of the lesion. In the first case, a 10yearold girl was admitted to the hospital on about the 10th day of illness with complaints of undefined abdominal pain, about which she had already twice applied to other hospitals in Moscow. SI was suspected on ultrasound and confirmed on CT, and then the echographic dynamics of SI was followed for more than 2 months. Against the background of anticoagulant, antibacterial and symptomatic therapy, recovery was achieved. In the second case, total SI was observed in a premature infant with severe multiple organ failure. The publication is extensively illustrated and contains a brief review of the literature.
Preoperative detection of perforator vessels in the perforator flap planning is an actual problem in clinical practice. There are various methods to visualize the localization of perforator vessels. This review presents the main of these methods with a description of their capabilities, advantages and limitations, as well as describes the priorities for using one or another approach depending on the localization of the donor site.